INT17802

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Context Info
Confidence 0.24
First Reported 1991
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 6.31
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
myocardium 2
plasma 1
Lung 1
kidney 1
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 74 100.00 Very High Very High Very High
pulpitis 2 98.40 Very High Very High Very High
anesthesia 6 95.80 Very High Very High Very High
Bioavailability 2 88.12 High High
cytokine 47 84.36 Quite High
Inflammatory response 9 71.04 Quite High
fibrosis 60 53.52 Quite High
imagery 3 44.96 Quite Low
Angina 6 28.72 Quite Low
cva 9 19.92 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 74 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 20 99.18 Very High Very High Very High
Sickle Cell Anemia 92 98.88 Very High Very High Very High
Hypoxia 94 98.68 Very High Very High Very High
Sprains And Strains 33 98.60 Very High Very High Very High
Pulpitis 2 98.40 Very High Very High Very High
Infection 78 98.28 Very High Very High Very High
Acute Chest Syndrome 70 98.20 Very High Very High Very High
Heart Disease 36 92.64 High High
Thrombosis 16 92.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uchida et al [51] and Sakamoto et al [52] reported that various cells within the kidney tissue either express mRNA for ET-1 or can synthesis ET-1 and thus it reveals that ET-1 may, therefore, have a paracrine or autocrine effect.
Transcription (express) of ET-1 in kidney
1) Confidence 0.24 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 0.91 Pain Relevance 0
The infection of CD1 mice with the Brazil strain and C57BL/6 mice with the Tulahuen strain caused an intense vasculitis, high plasma ET-1 levels, and increased expression of mRNAs for the precursor molecule preproET-1, endothelin converting enzyme (ECE), and ET-1 in the myocardium [76].
Transcription (expression) of ET-1 in myocardium associated with increased venous pressure under development, sprains and strains and infection
2) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.31 Pain Relevance 0.24
The infection of CD1 mice with the Brazil strain and C57BL/6 mice with the Tulahuen strain caused an intense vasculitis, high plasma ET-1 levels, and increased expression of mRNAs for the precursor molecule preproET-1, endothelin converting enzyme (ECE), and ET-1 in the myocardium [76].
Transcription (expression) of preproET-1 in myocardium associated with increased venous pressure under development, sprains and strains and infection
3) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 1.25 Pain Relevance 0.21
The consequences of T. cruzi infection of HUVECs with regard to the production of biologically active ET-1 are an increased expression of ET-1 mRNA [89].
Transcription (expression) of ET-1 associated with infection
4) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2930857 Disease Relevance 0.78 Pain Relevance 0.04
Lung mRNA levels of the inflammatory biomarkers VCAM-1, ICAM-1, and MCP-1, as well as of endothelin-1 (ET-1) were considerably higher after hypoxia than after normoxia, with no differences between IL-6-/- and wild-type mice (Figure 5).


Transcription (levels) of ET-1 in Lung associated with inflammation and hypoxia
5) Confidence 0.21 Published 2009 Journal Respir Res Section Body Doc Link PMC2644669 Disease Relevance 0.94 Pain Relevance 0.09
Endothelin-1 transcription may be induced by activation of the redox-sensitive NF-?
Transcription (transcription) of Endothelin-1
6) Confidence 0.09 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.52 Pain Relevance 0.04
Similarly, we demonstrated increased endothelin-1 mRNA and protein levels in endothelial cells exposed to plasma from ACS patients as compared with those exposed to plasma from SCD patients at baseline [52].
Transcription (levels) of endothelin-1 in plasma associated with sickle cell anemia and acute chest syndrome
7) Confidence 0.06 Published 2001 Journal Respir Res Section Body Doc Link PMC59517 Disease Relevance 0.51 Pain Relevance 0.04
Endothelin levels were analyzed by radioimmunoassay based on double antibody method using Silica ODS suspension.
Spec (analyzed) Transcription (levels) of Endothelin
8) Confidence 0.03 Published 1991 Journal Masui Section Abstract Doc Link 1942512 Disease Relevance 0 Pain Relevance 0.34
[Relative analysis of the mRNA expression between endothelin and inducible nitric oxide synthase in pulpitis].
Transcription (expression) of endothelin associated with pulpitis
9) Confidence 0.00 Published 1999 Journal Zhonghua Kou Qiang Yi Xue Za Zhi Section Title Doc Link 11776875 Disease Relevance 0.10 Pain Relevance 0.19

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