INT178024

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.31
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
retina 4
vestibular ganglion 2
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 4 100.00 Very High Very High Very High
antidepressant 73 98.64 Very High Very High Very High
Transcranial magnetic stimulation 3 97.64 Very High Very High Very High
antagonist 1 96.36 Very High Very High Very High
agonist 18 87.36 High High
Inflammation 17 80.16 Quite High
noradrenaline 1 77.92 Quite High
sSRI 1 76.60 Quite High
monoamine 2 74.20 Quite High
Neurotransmitter 7 70.08 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 381 100.00 Very High Very High Very High
Disease 43 100.00 Very High Very High Very High
Ganglion Cysts 19 100.00 Very High Very High Very High
Stress 88 99.56 Very High Very High Very High
Neurodegenerative Disease 46 97.96 Very High Very High Very High
Shock 10 96.86 Very High Very High Very High
Aging 2 92.72 High High
Anxiety Disorder 24 89.20 High High
Coronary Heart Disease 3 83.80 Quite High
INFLAMMATION 17 80.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and N-methyl-D-aspartate antagonists, electroconvulsive shock, and transcranial magnetic stimulation.98,109–114 Chronic treatment with antidepressants not only increases expression of BDNF in healthy rodents, but also reverses down-regulation of BDNF caused by stress.98,115,116 However, these effects depend on various factors, including length of administration, class of antidepressant, route of administration, age of animal, and doses of the drugs.
Negative_regulation (reverses) of Negative_regulation (regulation) of BDNF associated with stress, antidepressant, transcranial magnetic stimulation, antagonist and shock
1) Confidence 0.37 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.26 Pain Relevance 0.70
We also found that reduction of BDNF was attenuated by lutein, indicating that this change was partly caused by excessive oxidative stress.
Negative_regulation (attenuated) of Negative_regulation (reduction) of BDNF associated with stress
2) Confidence 0.33 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.57 Pain Relevance 0.04
Diabetes-induced reduction in BDNF was suppressed by lutein intake Since diabetes decreases one of the major trophic factors for retinal neurons, BDNF, we also measured BDNF by immunoblot analysis in the 1-month-diabetic retina.
Negative_regulation (suppressed) of Negative_regulation (reduction) of BDNF in retina associated with diabetes mellitus
3) Confidence 0.33 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 1.55 Pain Relevance 0
ERK activation, the subsequent synaptophysin reduction, and the BDNF depletion in the diabetic retina were all prevented by lutein.
Negative_regulation (prevented) of Negative_regulation (depletion) of BDNF in retina associated with diabetes mellitus
4) Confidence 0.33 Published 2010 Journal Diabetologia Section Abstract Doc Link PMC2850533 Disease Relevance 1.45 Pain Relevance 0
Strikingly, administration of deoxygedunin prevents vestibular ganglion loss in BDNF ?
Negative_regulation (prevents) of Negative_regulation (loss) of BDNF in vestibular ganglion associated with ganglion cysts
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.42 Pain Relevance 0.17
Interestingly, BDNF reductions have been found in HD patients [46] and decreased CREB-mediated transcription has been described in HD models [47].
Negative_regulation (decreased) of Negative_regulation (reductions) of BDNF associated with disease and bdmf
6) Confidence 0.21 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 1.06 Pain Relevance 0.09

General Comments

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