INT178026

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.14
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) extracellular region (Epo)
Anatomy Link Frequency
plasma 1
bone marrow 1
brains 1
synapses 1
Epo (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 226 99.04 Very High Very High Very High
Multiple sclerosis 2 98.48 Very High Very High Very High
Hippocampus 50 94.76 High High
Inflammation 245 90.40 High High
Inflammatory response 55 84.80 Quite High
ischemia 6 84.16 Quite High
dexamethasone 2 80.44 Quite High
Dopamine 4 79.48 Quite High
Inflammatory mediators 1 73.04 Quite High
bDMF 16 70.96 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 58 100.00 Very High Very High Very High
Anaemia 41 99.76 Very High Very High Very High
Chronic Progressive Multiple Sclerosis 2 99.28 Very High Very High Very High
Schizophrenia 6 99.16 Very High Very High Very High
Hypoxia 82 98.64 Very High Very High Very High
Cerebral Malaria 84 96.36 Very High Very High Very High
Respiratory Syncytial Virus 198 96.04 Very High Very High Very High
Apoptosis 144 95.92 Very High Very High Very High
Infection 202 95.68 Very High Very High Very High
Injury 24 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, an increase in cognitive performance upon EPO in patients with chronic progressive multiple sclerosis occurred independently of changes in hemoglobin levels, and persisted for months after termination of EPO treatment [4,19].
Positive_regulation (increase) of EPO associated with cognitive disorder, multiple sclerosis and chronic progressive multiple sclerosis
1) Confidence 0.70 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 1.14 Pain Relevance 0.16
Increased serum Epo levels promote survival of erythroid precursor cells of the bone marrow that would otherwise undergo apoptosis [8].
Positive_regulation (Increased) of Epo in bone marrow associated with apoptosis
2) Confidence 0.68 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 1.19 Pain Relevance 0.13
The vasopressor action of rHuEPO may be mediated by several mechanisms, including a direct vasopressor effect on the smooth muscle cells [25,26], and by increasing the circulating plasma levels of the endothelin-1 [27-29].
Positive_regulation (mediated) of rHuEPO in plasma
3) Confidence 0.50 Published 2007 Journal Crit Care Section Body Doc Link PMC2206412 Disease Relevance 0.66 Pain Relevance 0.05
Synaptic plasticity is significantly increased at Schaffer collateral CA1 synapses in EPO-treated mice
Positive_regulation (increased) of EPO in synapses
4) Confidence 0.50 Published 2008 Journal BMC Biol Section Body Doc Link PMC2562991 Disease Relevance 0.19 Pain Relevance 0.12
This result suggests that the angiogenic activity of EPO on HUVECs is indirect, and could be mediated by stimulating other growth factors, such as bFGF and PDGF-BB, and proteases such MMP-2.
Positive_regulation (proteases) of EPO
5) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.22 Pain Relevance 0
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
Positive_regulation (increase) of EPO
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.06
This result suggests that the angiogenic activity of EPO on HUVECs is indirect, and could be mediated by stimulating other growth factors, such as bFGF and PDGF-BB, and proteases such MMP-2.
Positive_regulation (mediated) of EPO
7) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.22 Pain Relevance 0
ML provided the asialoEPO and conceived of the study.
Positive_regulation (provided) of asialoEPO
8) Confidence 0.46 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.34 Pain Relevance 0.07
Having these current findings of the neuro-protective effect of Epo and the fact that endogenous Epo levels are high in children with SMA in mind, it can be proposed that these increased levels of endogenous Epo in very young children could contribute to this apparent dichotomy, by protecting against CM.


Positive_regulation (increased) of Epo associated with anaemia and cerebral malaria
9) Confidence 0.45 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 1.36 Pain Relevance 0.04
Reduced BrdU labeling in R6/2 mouse brains, but no increase by asialoEPO administration
Neg (no) Positive_regulation (increase) of asialoEPO in brains
10) Confidence 0.40 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.07 Pain Relevance 0.07
CIS is induced by cytokines that activate STAT5 and bind to receptors that activate STAT5, namely erythropoietin, IL-2, IL-3, prolactin and growth hormone (GH) [11].
Positive_regulation (activate) of erythropoietin associated with cytokine
11) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.11 Pain Relevance 0.17
A number of elegant studies, exemplified by those defining induction of the erythropoietin (EPO) gene [1], [2], have utilized multidisciplinary approaches to elucidate basic hypoxia-adaptive responses.
Positive_regulation (induction) of EPO associated with hypoxia
12) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.53 Pain Relevance 0
A number of elegant studies, exemplified by those defining induction of the erythropoietin (EPO) gene [1], [2], have utilized multidisciplinary approaches to elucidate basic hypoxia-adaptive responses.
Positive_regulation (induction) of erythropoietin associated with hypoxia
13) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.53 Pain Relevance 0
Hypoxia-inducing factor-1 (HIF-1) is a transcription factor that regulates activation of several genes responsive to low oxygen, including erythropoietin, vascular endothelial growth factor, glycolytic enzymes, and glucose transporters.
Positive_regulation (activation) of erythropoietin associated with hypoxia
14) Confidence 0.03 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 1.29 Pain Relevance 0.08

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