INT178027

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Context Info
Confidence 0.54
First Reported 2004
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 11.62
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
cleavage 1
nucleus 1
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 2 73.08 Quite High
Bioavailability 2 69.40 Quite High
cytokine 10 62.84 Quite High
depression 13 56.40 Quite High
methotrexate 1 54.60 Quite High
vincristine 1 53.60 Quite High
headache 11 51.28 Quite High
projection neuron 1 48.24 Quite Low
Hippocampus 4 19.84 Low Low
Bile 1 17.84 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 253 100.00 Very High Very High Very High
Melanoma 803 99.84 Very High Very High Very High
Death 43 99.74 Very High Very High Very High
Ovarian Cancer 110 99.30 Very High Very High Very High
Cancer 486 99.28 Very High Very High Very High
Congenital Anomalies 1 92.80 High High
Nevus 242 91.64 High High
Adhesions 6 91.32 High High
Metastasis 85 88.08 High High
Malignant Neoplastic Disease 119 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we showed that pretreatment of chemotherapy-resistant ovarian cancer cells with Phenoxodiol results in decreases in XIAP levels and sensitization to Gemcitabine, Carboplatin and Paclitaxel [19].
Negative_regulation (decreases) of XIAP associated with ovarian cancer
1) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.56 Pain Relevance 0
While it is unknown whether there is a threshold level above which XIAP inhibitors might be more effective as therapeutics, our data show that there is variability in XIAP expression in melanoma, which should, at the very least, be assessed when XIAP targeting therapies are used in clinical trials in melanoma patients.
Negative_regulation (inhibitors) of XIAP associated with melanoma
2) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.99 Pain Relevance 0
The two pathways are inhibited by a group of proteins called the IAP (inhibitors of apoptosis) proteins, of which the X-linked inhibitor of apoptosis protein (XIAP) is a key member.
Negative_regulation (inhibitor) of XIAP associated with apoptosis
3) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.97 Pain Relevance 0
A further decrease in XIAP levels was seen at 8 hours post treatment and no expression was observed at 24 hours (Figure 6A).
Negative_regulation (decrease) of XIAP
4) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.38 Pain Relevance 0
The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

XIAP up-regulation is associated with chemotherapy resistance.

Negative_regulation (inhibitor) of XIAP in cleavage associated with melanoma and apoptosis
5) Confidence 0.54 Published 2007 Journal J Transl Med Section Title Doc Link PMC1796544 Disease Relevance 0.98 Pain Relevance 0
We showed that inhibition of XIAP by RNA interference yields sensitization to Docetaxel similar to that seen with Phenoxodiol [17].
Negative_regulation (inhibition) of XIAP
6) Confidence 0.54 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.88 Pain Relevance 0
This effect is dependent upon the activation of the caspase system and inhibiting XIAP [30].
Negative_regulation (inhibiting) of XIAP
7) Confidence 0.47 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.13 Pain Relevance 0
Although the precise target of Phenoxodiol remains unknown, it inhibits XIAP by causing early, caspase independent self-ubiquitination and degradation of XIAP by the proteasome [19].
Negative_regulation (inhibits) of XIAP
8) Confidence 0.40 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.71 Pain Relevance 0.08
Down-regulation of XIAP in melanoma cells by siRNAs sensitizes these cells to TRAIL-induced apoptosis [24].
Negative_regulation (regulation) of XIAP associated with melanoma and apoptosis
9) Confidence 0.40 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.31 Pain Relevance 0
A number of preclinical studies have demonstrated efficacy of XIAP inhibitors for a variety of tumors [13,22,23].
Negative_regulation (inhibitors) of XIAP associated with cancer
10) Confidence 0.35 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.28 Pain Relevance 0
Exposure of YUMAC cells to Phenoxodiol decreased the level of XIAP at 4 hours compared with pretreament levels.
Negative_regulation (decreased) of XIAP
11) Confidence 0.35 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.39 Pain Relevance 0
The activation of this pathway has been linked to the activation and nuclear translocation of nuclear factor-kB (NFkB), which once in the nucleus, can lead to the up-regulation of neuroprotective genes (e.g., the caspase inhibitors: X-linked inhibitor of apoptosis proteins, XIAP, and cellular inhibitor of apoptosis proteins-2, c-IAP2) [32].
Negative_regulation (inhibitor) of XIAP in nucleus associated with apoptosis
12) Confidence 0.29 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.65 Pain Relevance 0.04
Moreover, TM treatment also significantly enhanced tumor cell anoikis by activating p38 MAPK cell death pathway and downregulating XIAP survival proteins.


Negative_regulation (downregulating) of XIAP associated with cancer and death
13) Confidence 0.25 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.16 Pain Relevance 0.07
Of note, a combination of the inhibition of P-glycoprotein with the inhibition of the antiapoptotic proteins Bcl-2, Bcl-xL, and XIAP showed an even higher increase in chemosensitivity, up to 5.5 fold [12].
Negative_regulation (inhibition) of XIAP
14) Confidence 0.13 Published 2011 Journal Sarcoma Section Body Doc Link PMC3018623 Disease Relevance 0.24 Pain Relevance 0.05

General Comments

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