INT17803

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Context Info
Confidence 0.54
First Reported 1990
Last Reported 2007
Negated 2
Speculated 3
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 4.75
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1)
cytoplasm (Edn1)
Anatomy Link Frequency
plasma 3
blood 2
macrophages 1
liver 1
forearm 1
Edn1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 26 100.00 Very High Very High Very High
qutenza 16 100.00 Very High Very High Very High
anesthesia 13 100.00 Very High Very High Very High
Antinociceptive 3 99.98 Very High Very High Very High
algogenic 1 99.98 Very High Very High Very High
Intracerebroventricular 1 99.52 Very High Very High Very High
Inflammation 16 99.32 Very High Very High Very High
Morphine 4 98.74 Very High Very High Very High
COX2 9 98.50 Very High Very High Very High
Somatic pain 1 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 8 99.84 Very High Very High Very High
Bone Disease 7 99.74 Very High Very High Very High
INFLAMMATION 29 99.32 Very High Very High Very High
Syndrome 3 99.24 Very High Very High Very High
Disorders Of Creatine Metabolism 1 98.76 Very High Very High Very High
Motor Neuron Diseases 107 97.00 Very High Very High Very High
Injury 4 96.60 Very High Very High Very High
Pain 6 96.24 Very High Very High Very High
Poisoning 13 96.20 Very High Very High Very High
Hypoxia 6 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated a possible correlation between ET-1 plasma concentrations and bone metabolism in patients with PD and whether ET-1 plasma levels are regulated by i. v. bisphosphonate treatment.
Spec (whether) Regulation (regulated) of ET-1 in plasma associated with bone disease
1) Confidence 0.54 Published 2005 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 16320159 Disease Relevance 0.61 Pain Relevance 0.09
In group 1, the ET-1 level decreased significantly at second blood samplings (2.5+/-0.4 pmol/L versus 1.7+/-0.6 pmol/L, P <.001), whereas there were no definite changes of ET-1 levels in group 2 (2.5+/-0.5 pmol/L versus 2.6+/-0.6 pmol/L, P =not significant).
Neg (no) Regulation (changes) of ET-1 in blood
2) Confidence 0.50 Published 2001 Journal Ann Emerg Med Section Body Doc Link 11326179 Disease Relevance 0 Pain Relevance 0
L-NAME showed slight insignificant antinociceptive action, but augmented significantly the antinociceptive effects of i.c.v. administered ET-1 and ET-3 in both experimental tests.
Regulation (effects) of ET-1 associated with antinociceptive
3) Confidence 0.45 Published 1994 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 7837829 Disease Relevance 0 Pain Relevance 0.18
Effects of endothelin-1 on capsaicin-induced nociception in mice.
Regulation (Effects) of endothelin-1 associated with nociception and qutenza
4) Confidence 0.43 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9698200 Disease Relevance 0.49 Pain Relevance 0.81
The influence of endothelin-1 on nociception induced by capsaicin was assessed in the mouse hindpaw.
Regulation (influence) of endothelin-1 associated with nociception and qutenza
5) Confidence 0.43 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698200 Disease Relevance 0.32 Pain Relevance 0.51
We observed the changes of plasma endothelin, hemodynamic and electrocardiogram in twelve patients undergone upper abdominal surgery under epidural anesthesia.
Regulation (changes) of plasma endothelin in upper associated with anesthesia and epidural
6) Confidence 0.37 Published 1997 Journal Hunan Yi Ke Da Xue Xue Bao Section Abstract Doc Link 10073030 Disease Relevance 0 Pain Relevance 0.14
The possible algogenic effects of elevated serum endothelin levels in cardiac syndrome X were investigated in a case-control study that examined somatic pain perception in the forearm during submaximal effort tourniquet and cold immersion tests.
Spec (possible) Regulation (effects) of serum endothelin in forearm associated with pain, algogenic, syndrome and somatic pain
7) Confidence 0.33 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9294999 Disease Relevance 0.51 Pain Relevance 0.42
Effects of prior exposure of pial arterioles to endothelin-1 (ET-1) (10(-9) M) on the constriction induced by the by-products of hemolyzed blood (5-HT, LTC4, LPA, and thromboxane analog U-46619) were examined.
Spec (examined) Regulation (Effects) of ET-1 in blood
8) Confidence 0.25 Published 2000 Journal Life Sci. Section Abstract Doc Link 10665982 Disease Relevance 0 Pain Relevance 0.12
We conclude that endothelin-1 increases cyclooxygenase 2 protein expression and prostaglandin E2 production via mainly endothelin ET(B) receptors and partly endothelin ET(A) receptors in macrophages; however, lipopolysaccharide increases both cyclooxygenase 2 protein expression and prostaglandin E2 production in pacrophages without involving endothelin ET(A) or ET(B) receptor-mediated processes.
Neg (without) Regulation (involving) of endothelin in macrophages associated with cox2
9) Confidence 0.23 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9761426 Disease Relevance 0.06 Pain Relevance 0.54
STUDY OBJECTIVE: Morphine has multiple cardiovascular effects, but its action on hydrolysis of endothelin 1 (ET-1) has not been investigated.
Regulation (action) of ET-1 associated with morphine
10) Confidence 0.22 Published 2001 Journal Ann Emerg Med Section Abstract Doc Link 11326179 Disease Relevance 0.07 Pain Relevance 0.17
For instance, the up-regulated EDN1, encoding a pro-inflammatory vasoconstrictor peptide, exerts a variety of ALS-aggravating effects, including axonal degeneration [97], impairment of water homeostasis, heightened sensitivity to hypoxic stress [98], and increased excitotoxicity [99].
Regulation (regulated) of EDN1 associated with stress, inflammation, hypoxia and motor neuron diseases
11) Confidence 0.18 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 1.31 Pain Relevance 0.38
Annand et al [8] reported that GalN intoxication causes liver injury followed by renal impairment, which is manifested by the decrease in renal blood flow, creatinine clearance as well as increase in plasma ET-1 concentration and also up-regulation of ET-1 receptor in renal cortex although kidneys are histologically normal.
Regulation (regulation) of ET-1 in liver associated with disorders of creatine metabolism, injury and poisoning
12) Confidence 0.16 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC1868763 Disease Relevance 1.11 Pain Relevance 0
Effects of anesthesia and surgery on plasma endothelin levels.
Regulation (Effects) of plasma endothelin in plasma associated with anesthesia
13) Confidence 0.03 Published 1995 Journal Anesth. Analg. Section Title Doc Link 7864406 Disease Relevance 0.05 Pain Relevance 0.45
[Changes in plasma endothelin in patients undergoing cardiac valve replacement under high dose fentanyl anesthesia].
Regulation ([Changes) of endothelin in plasma associated with anesthesia
14) Confidence 0.02 Published 1991 Journal Masui Section Title Doc Link 1942512 Disease Relevance 0 Pain Relevance 0.34
may influence the ovarian vasculature by its ability to regulate endothelin-1 (ET-1) and nitric oxide synthase (NOS).
Regulation (regulate) of ET-1 in vasculature
15) Confidence 0.01 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0 Pain Relevance 0.05
[Homologous and heterologous regulations of endothelin receptors on smooth muscle cells].
Regulation (regulations) of endothelin in smooth muscle cells
16) Confidence 0.00 Published 1990 Journal Arch Mal Coeur Vaiss Section Title Doc Link 2175581 Disease Relevance 0 Pain Relevance 0.16
Central effects of endothelin and its antagonists on sympathetic and cardiovascular regulation in SHR-SP.
Regulation (regulation) of endothelin in sympathetic associated with anesthesia and antagonist
17) Confidence 0.00 Published 1999 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 10367590 Disease Relevance 0.21 Pain Relevance 0.34

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