INT178030

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.03
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) extracellular region (Epo)
Anatomy Link Frequency
fat 2
bone marrow 2
fibroblasts 1
Epo (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 4 99.92 Very High Very High Very High
adenocard 159 99.32 Very High Very High Very High
Inflammation 154 99.04 Very High Very High Very High
cytokine 91 98.52 Very High Very High Very High
tolerance 6 92.44 High High
ischemia 287 88.68 High High
Dopamine 2 86.80 High High
metalloproteinase 6 64.08 Quite High
agonist 42 54.00 Quite High
Inflammatory response 22 28.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 167 99.04 Very High Very High Very High
Anaemia 26 98.32 Very High Very High Very High
Hypoxia 45 96.66 Very High Very High Very High
Graft Vs Host Disease 4 94.28 High High
Diabetes Mellitus 14 94.08 High High
Disease 45 94.04 High High
Wound Healing 92 92.92 High High
Apoptosis 75 92.64 High High
Thalassemia 2 89.52 High High
Cv Unclassified Under Development 272 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, erythropoietin (Epo) gene transfer appears to be a promising alternative for severe anaemia treatment since it requires less frequent treatment repeat and may allow sustained Epo secretion and constant patient coverage.
Localization (secretion) of Epo associated with anaemia
1) Confidence 0.78 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2276190 Disease Relevance 0.62 Pain Relevance 0
AsialoEPO asialoerythropoietin
Localization (asialoerythropoietin) of AsialoEPO
2) Confidence 0.74 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC434499 Disease Relevance 0.30 Pain Relevance 0.09
These systems could avoid deleterious Epo secretion peak, but unsolved problems such as host immune response against the transactivator [10] or inducing agents adverse effects, are still restricting their use.
Localization (secretion) of Epo
3) Confidence 0.73 Published 2008 Journal Genet Vaccines Ther Section Body Doc Link PMC2276190 Disease Relevance 0.40 Pain Relevance 0
On the other hand, EPO has no effect on the proliferation of HUVECs that were exposed to the above mentioned inhibitors simultaneously, supporting the idea that secretion of a cluster of growth factors accounts, at least, to one of the underlying mechanisms of EPO action on fat graft vascularization.
Localization (secretion) of EPO in fat
4) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.11 Pain Relevance 0
Indeed, the increased VEGFR-2 expression in the EPO-treated fat grafts that was observed in our study implies that EPO-induced endogenous VEGF secretion in the fat grafts might be more effective than exogenous VEGF administration.
Localization (secretion) of EPO in fat
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.36 Pain Relevance 0.03
As the major stromal cells in the bone marrow, BM-MSCs have been known to release factors such as erythropoietin (EPO) and granulocyte colony-stimulating factor (G-CSF) supporting the survival, proliferation and differentiation of hematopoietic stem/progenitor cells.
Localization (release) of erythropoietin in bone marrow
6) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.93 Pain Relevance 0.10
As the major stromal cells in the bone marrow, BM-MSCs have been known to release factors such as erythropoietin (EPO) and granulocyte colony-stimulating factor (G-CSF) supporting the survival, proliferation and differentiation of hematopoietic stem/progenitor cells.
Localization (release) of EPO in bone marrow
7) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.93 Pain Relevance 0.10
, erythropoietin and stromal cell-derived factor-1, while dermal fibroblasts secreted greater amounts of pro-inflammatory cytokines such as interleukin-6 [31].
Localization (secreted) of erythropoietin in fibroblasts associated with inflammation and cytokine
8) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743192 Disease Relevance 0.26 Pain Relevance 0.35
Subcutaneously implanted MSCs engineered to release erythropoietin to allogeneic mice were found to cause shorter lasting increase in hematocrit than to syngeneic mice, and allogeneic MSC implants had an increased proportion of host-derived lymphoid CD8+, natural killer T (NKT), and NK infiltrating cells compared with syngeneic controls [15], suggesting that immune reaction to allo-MSCs may caused reduced cell engraftment.
Localization (release) of erythropoietin
9) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743192 Disease Relevance 0.46 Pain Relevance 0.05
Taken together these studies rule out a contribution of extracellular adenosine generation or signaling on renal erythropoietin release.
Localization (release) of erythropoietin associated with adenocard
10) Confidence 0.30 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.64 Pain Relevance 0.40
However, recent work tested the influence of adenosine generation and signaling on renal erythropoietin release using genetic and pharmacological approaches [60,61].
Localization (release) of erythropoietin associated with adenocard
11) Confidence 0.26 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.47 Pain Relevance 0.36
As previous studies have shown an important role of erythropoietin in tissue adaptation to hypoxia [58] or preconditioning [59], it would be tempting to speculate that extracellular adenosine generation and signaling (e.g., through the A2BAR) could influence renal erythropoietin secretion, e.g., as part of an autocrine feedback loop.
Localization (secretion) of erythropoietin associated with adenocard and hypoxia
12) Confidence 0.26 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.54 Pain Relevance 0.37

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