INT17805

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.88
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophils 6
granulocyte 2
pancreas 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 102 100.00 Very High Very High Very High
cINOD 6 100.00 Very High Very High Very High
anesthesia 5 98.64 Very High Very High Very High
cytokine 58 88.80 High High
Inflammatory response 20 87.84 High High
Osteoarthritis 44 59.36 Quite High
fibrosis 28 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 130 100.00 Very High Very High Very High
Renal Failure 1 96.40 Very High Very High Very High
Bronchiectasis 70 95.68 Very High Very High Very High
Disease 27 93.68 High High
Necrosis 16 85.64 High High
Apoptosis 59 84.20 Quite High
Osteoarthritis 48 59.36 Quite High
Infection 14 58.08 Quite High
Sepsis 1 57.52 Quite High
Cirrhosis 45 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of some anti-inflammatory agents on elastase release from neutrophils in-vitro.
Regulation (effect) of Localization (release) of elastase in neutrophils associated with inflammation
1) Confidence 0.59 Published 1990 Journal J. Pharm. Pharmacol. Section Title Doc Link 1980289 Disease Relevance 0.27 Pain Relevance 0.22
[The effects of ulinastatin on the release of granulocyte elastase during pancreas surgery].
Regulation (effects) of Localization (release) of elastase in pancreas
2) Confidence 0.32 Published 1990 Journal Masui Section Title Doc Link 2232129 Disease Relevance 0 Pain Relevance 0.07
[Changes in granulocyte elastase caused by the use of ulinastatin during anesthesia for renal transplantation].
Regulation ([Changes) of Localization (caused) of granulocyte elastase in granulocyte associated with anesthesia
3) Confidence 0.28 Published 1991 Journal Masui Section Title Doc Link 1942515 Disease Relevance 0.21 Pain Relevance 0.24
In view of the potential role of released polymorphonuclear leucocyte elastase in causing tissue damage, the effect of commonly used anti-inflammatory drugs on elastase release from neutrophils has been studied in-vitro.
Regulation (effect) of Localization (release) of elastase in polymorphonuclear leucocyte associated with inflammation and cinod
4) Confidence 0.26 Published 1990 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 1980289 Disease Relevance 0.25 Pain Relevance 0.21
HNE-induced LTB4 release through 5-LOX and FLAP upregulation
Regulation (through) of Localization (release) of HNE-induced
5) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.19 Pain Relevance 0.10
Such a discrepancy between the effects reported for ROS and HNE is likely to depend on the different mechanisms of action: although Uchida and coworkers [23,332] have proposed that, in some cells, HNE may result in mitochondrial damage and subsequent release of ROS (at high concentrations, however, such as 20 ?
Regulation (effects) of Localization (reported) of HNE
6) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.05 Pain Relevance 0
Since IL-8 can activate neutrophils by increasing degranulation and neutrophil elastase release, our attention has been focused on its pivotal and fundamental responsibility for bronchial destruction in bronchiectasis due to sulfur mustard gas inhalation [30].
Regulation (degranulation) of Localization (release) of neutrophil elastase in neutrophils associated with bronchiectasis
7) Confidence 0.05 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1781448 Disease Relevance 0.90 Pain Relevance 0.24

General Comments

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