INT17807

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Context Info
Confidence 0.06
First Reported 1991
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.28
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFC) extracellular region (PDGFC) nucleus (PDGFC)
cytoplasm (PDGFC)
Anatomy Link Frequency
spinal cord 2
platelet 2
PDGFC (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 187 100.00 Very High Very High Very High
Central nervous system 4 95.60 Very High Very High Very High
backache 1 84.00 Quite High
Pain 8 80.40 Quite High
cva 15 77.72 Quite High
vincristine 3 58.56 Quite High
iatrogenic 2 58.00 Quite High
syringomyelia 22 49.48 Quite Low
medulla 2 36.80 Quite Low
fibrosis 1 7.72 Low Low
Disease Link Frequency Relevance Heat
Injury 2 99.64 Very High Very High Very High
Hypoxia 2 99.04 Very High Very High Very High
Scoliosis 606 96.08 Very High Very High Very High
Reticulocytosis 1 92.84 High High
Thrombosis 14 88.40 High High
Thrombosis Related Under Development 11 87.44 High High
Anaemia 1 85.76 High High
Cancer 25 85.32 High High
Hemorrhage 3 84.52 Quite High
Low Back Pain 1 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug has also been found to be synergistic with the platelet growth factor thrombopoietin for platelet activation and is associated with increased platelet reactivity and endothelial activation.
Positive_regulation (activation) of platelet growth factor in platelet
1) Confidence 0.06 Published 2007 Journal The Open Respiratory Medicine Journal Section Body Doc Link PMC2596356 Disease Relevance 1.43 Pain Relevance 0.16
Porter [28] stated that the putative impaired growth of the spinal cord in AIS may result from an abnormal response to stretch including: 1) inadequate cord growth from deficient hormonal environment; 2) cell membrane defect with abnormal function of contractile proteins in cells of the spinal cord as part of a systemic disorder; 3) abnormality of the elastin fibre system, 4) failure of melatonin to scavenge free radicals resulting in spinal cord stretch injury; and 5) hypoxia.


Positive_regulation (resulting) of spinal cord in spinal cord associated with scoliosis, hypoxia, injury and spinal cord
2) Confidence 0.06 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.59 Pain Relevance 0.33
c) Such cord 'understretch' would require an abnormal spinal cord.
Positive_regulation (require) of spinal cord in spinal cord associated with spinal cord
3) Confidence 0.05 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.65 Pain Relevance 0.18
Serum vitamin B12 and plasma platelet-derived growth factor level were elevated.
Positive_regulation (elevated) of plasma platelet-derived growth factor in platelet
4) Confidence 0.05 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 1942535 Disease Relevance 0.60 Pain Relevance 0.19

General Comments

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