INT178072

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.11
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EDN3) extracellular space (EDN3) extracellular region (EDN3)
plasma membrane (EDNRB) cell-cell signaling (EDN3) signal transducer activity (EDNRB)
Anatomy Link Frequency
keratinocytes 2
EDNRB (Homo sapiens)
EDN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8 97.08 Very High Very High Very High
antagonist 29 67.92 Quite High
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 14 99.12 Very High Very High Very High
Cancer 65 92.80 High High
Malignant Neoplastic Disease 6 84.16 Quite High
Adhesions 4 71.44 Quite High
Death 3 69.76 Quite High
Sarcoma 9 35.80 Quite Low
Immunotherapy Of Cancer 2 22.04 Low Low
Recurrence 1 15.08 Low Low
Disease 2 5.72 Low Low
Ovarian Cancer 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regards ET-1 and ET-3 by ETBR signalling induce the inactivation of the gap junctions through the phosphorylation of the Cx43, which are responsible for contact mediated regulatory control of keratinocytes.
Gene_expression (signalling) of ETBR in keratinocytes Positive_regulation (regards) of ET-3
1) Confidence 0.05 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.11 Pain Relevance 0.08

General Comments

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