INT17808

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Context Info
Confidence 0.44
First Reported 1985
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 10.70
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (NTS) extracellular region (NTS)
Anatomy Link Frequency
spinal cord 1
neuron 1
sympathetic 1
brainstem 1
NTS (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 22 100.00 Very High Very High Very High
Calcitonin gene-related peptide 6 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Somatostatin 1 100.00 Very High Very High Very High
Serotonin 1 100.00 Very High Very High Very High
medulla 11 99.96 Very High Very High Very High
Cholecystokinin 2 99.06 Very High Very High Very High
alcohol 55 99.04 Very High Very High Very High
Dismenorea 7 98.40 Very High Very High Very High
Dorsal horn 2 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 558 100.00 Very High Very High Very High
Infection 22 99.96 Very High Very High Very High
Cancer 7 99.76 Very High Very High Very High
Sprains And Strains 20 99.74 Very High Very High Very High
Fatty Liver 168 99.56 Very High Very High Very High
Stress 1 98.84 Very High Very High Very High
Reprotox - General 1 7 98.40 Very High Very High Very High
Syndrome 98 97.80 Very High Very High Very High
INFLAMMATION 24 97.16 Very High Very High Very High
Cystitis 1 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, peptides which reduce food intake, increase sympathetic activity, with glucagon, cholecystokinin, corticotropin releasing hormone, calcitonin, neurotensin and bombesin being examples, Several of these peptides also affect the intake of specific nutrients.
Regulation (affect) of neurotensin in sympathetic associated with cholecystokinin
1) Confidence 0.44 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8489134 Disease Relevance 0 Pain Relevance 0.42
Broiler-chicken NTS: characteristics and serotypes
Regulation (serotypes) of NTS
2) Confidence 0.37 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.68 Pain Relevance 0.09
Therefore, we presume that these human NTS serovars are related to corresponding serovars from animal sources, and that a few dominant strains are largely responsible for NTS infection in human and in broiler-chicken.
Regulation (responsible) of NTS associated with sprains and strains and infection
3) Confidence 0.37 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693839 Disease Relevance 0.38 Pain Relevance 0
Direct swallow facilitation can occur when the proper stimuli affect responsive receptive fields with sensory fibers that synapse in the brainstem, exciting the dorsal region around the NTS [54].
Regulation (exciting) of NTS in brainstem associated with medulla
4) Confidence 0.29 Published 2010 Journal Dysphagia Section Body Doc Link PMC2992653 Disease Relevance 0 Pain Relevance 0.20
In addition to positive carcinoembryonic antigen and cytokeratin, the argyrophilic cancer cells were immunoreactive for neuron-specific enolase, chromogranin A, serotonin, neuropeptide Y, glicentin, somatostatin, neurotensin and calcitonin.
Regulation (immunoreactive) of neurotensin in neuron associated with cancer, somatostatin, neuropeptide and serotonin
5) Confidence 0.26 Published 1991 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 1942551 Disease Relevance 1.19 Pain Relevance 0.22
Neurotensin, human pancreatic peptide, vasoactive intestinal polypeptide, gastrin, and bombesin-like immunoreactivity levels did not reveal significant changes between days 7 and 25 in patients with PMS.
Neg (not) Regulation (changes) of Neurotensin associated with dismenorea
6) Confidence 0.16 Published 1985 Journal Fertil. Steril. Section Abstract Doc Link 2934273 Disease Relevance 0.63 Pain Relevance 0.71
We therefore investigated the possible involvement of various sensory neuropeptides including CGRP, substance P, galanin, neurotensin and neuropeptide Y and their receptors in the dorsal horn of the spinal cord during the development of tolerance to the antinociceptive action of intrathecal morphine.
Spec (possible) Regulation (involvement) of neurotensin in spinal cord associated with dorsal horn, antinociceptive, morphine, spinal cord, calcitonin gene-related peptide, neuropeptide, tolerance, substance p and intrathecal
7) Confidence 0.10 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7752094 Disease Relevance 0.09 Pain Relevance 1.60
Then different values of k are chosen to evaluate its influence on kNN and ML-kNN.
Regulation (influence) of kNN
8) Confidence 0.09 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2921356 Disease Relevance 0.18 Pain Relevance 0
Sensitivity analyses revealed that the NT AUROCs for the diagnosis of NASH (Table 6) and the diagnosis of borderline NASH or NASH (Table 7) were not affected by groups, ALT values, alcohol consumption, Gilbert's syndrome, acute inflammation, absence of steatosis, or biopsy sample length.
Neg (not) Regulation (affected) of NT associated with nash(non-alcoholic steatohepatitis), inflammation, syndrome and alcohol
9) Confidence 0.05 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.48 Pain Relevance 0.10
The diagnostic value of NT was also estimated using the pathologist determination of Nash or no Nash.
Regulation (value) of NT associated with nash(non-alcoholic steatohepatitis)
10) Confidence 0.03 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.25 Pain Relevance 0.11
Indeed the value of NT for this diagnostic of NASH was fair (AUROC = 0.80 in the validation group).
Regulation (value) of NT associated with nash(non-alcoholic steatohepatitis)
11) Confidence 0.03 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 0.88 Pain Relevance 0
When screened patients without histological steatosis were included in a sensitivity analysis the diagnostic value of NT was not different than in patients with steatosis only.
Regulation (value) of NT
12) Confidence 0.03 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.44 Pain Relevance 0.06
However when males consuming 30 g or women 20 g or more per day were excluded (only a total of 12 patients) according to recent guidelines for the diagnosis of NAFLD [45], the diagnostic value of NT was not significantly changed (Table 6 and Table 7).
Regulation (value) of NT associated with fatty liver
13) Confidence 0.03 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 0.58 Pain Relevance 0.16
Diagnostic values of NT for predicting borderline NASH and NASH in different groups, are given in Table 4 for the concordance with biopsy results, and in Table 5 for sensitivity, specificity and predictive values.
Regulation (values) of NT associated with nash(non-alcoholic steatohepatitis)
14) Confidence 0.03 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.22 Pain Relevance 0.08
These low molecular weight proteins, particularly oxytocin, AVP, TRH, neurotensin, and substance P, profoundly affect social behaviour, emotions, stress level, responsivity, reward-seeking and positive reinforcement behaviour [3].
Regulation (affect) of neurotensin associated with stress and substance p
15) Confidence 0.03 Published 2005 Journal BMC Psychiatry Section Body Doc Link PMC1190193 Disease Relevance 0.70 Pain Relevance 0.27

General Comments

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