INT178083

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.80
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1, VEGFA) extracellular region (EDN1, VEGFA) cytoplasm (EDN1, VEGFA)
growth (VEGFA) proteinaceous extracellular matrix (VEGFA) cell-cell signaling (EDN1)
EDN1 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 58 99.74 Very High Very High Very High
metalloproteinase 16 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
nociceptor 4 5.00 Very Low Very Low Very Low
Pain refractory 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 18 98.76 Very High Very High Very High
Cancer 130 97.60 Very High Very High Very High
Ovarian Cancer 46 88.16 High High
Reprotox - General 1 32 5.00 Very Low Very Low Very Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Skin Cancer 28 5.00 Very Low Very Low Very Low
Metastasis 26 5.00 Very Low Very Low Very Low
Sarcoma 18 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Osteoporosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of a specific ETAR antagonist blocked the ET-1-induced upregulation of VEGF expression and secretion as well as the ET-1-induced activation of HIF-1 transcription complex.
ET-1-induced Positive_regulation (upregulation) of Gene_expression (expression) of VEGF associated with antagonist
1) Confidence 0.09 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.00 Pain Relevance 0.08
ET-1 promotes VEGF production through HIF-1?
ET-1 Positive_regulation (promotes) of Gene_expression (production) of VEGF
2) Confidence 0.08 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.79 Pain Relevance 0.05

General Comments

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