INT178084

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (EDNRA, GJA1) signal transduction (EDNRA, GJA1) plasma membrane (EDNRA, GJA1)
transport (GJA1) aging (EDNRA) Golgi apparatus (GJA1)
EDNRA (Homo sapiens)
GJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 70.28 Quite High
metalloproteinase 8 53.72 Quite High
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 23 99.66 Very High Very High Very High
Cancer 65 79.84 Quite High
Malignant Neoplastic Disease 6 76.72 Quite High
Metastasis 13 75.12 Quite High
Osteoporosis 8 54.08 Quite High
Apoptosis 16 7.96 Low Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low
Hypoxia 9 5.00 Very Low Very Low Very Low
Sarcoma 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ovarian carcinoma cells, ET-1 via ETAR induces a transient and a dose-dependent reduction of GJIC (50–75%) and phosphorylates Cx43 through Src tyrosine kinase pathway indicating that ET-1 promotes cellular uncoupling at the level of connexin maturation and subsequent degradation [29].
ETAR Positive_regulation (phosphorylates) of Phosphorylation (phosphorylates) of Cx43 associated with ovarian cancer
1) Confidence 0.10 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.88 Pain Relevance 0.06

General Comments

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