INT178086

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Context Info
Confidence 0.07
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.82
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (EDNRA, PTK2) plasma membrane (EDNRA, PTK2) aging (EDNRA)
extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
EDNRA (Homo sapiens)
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 96.32 Very High Very High Very High
metalloproteinase 8 89.64 High High
withdrawal 1 6.52 Low Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 65 98.52 Very High Very High Very High
Metastasis 13 91.48 High High
Ovarian Cancer 23 84.84 Quite High
Malignant Neoplastic Disease 6 79.68 Quite High
Apoptosis 16 43.88 Quite Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low
Hypoxia 9 5.00 Very Low Very Low Very Low
Sarcoma 9 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore in these cells, ET-1 stimulated FAK and paxillin phosphorylation through ETAR binding [13] which directly correlated with tumor cell migration and invasion suggesting that ETAR antagonist can inhibit cell migration and possibly other FAK-associated processes which also contributes to invasion and metastasis in this tumor [28].
ETAR Binding (binding) of FAK associated with cancer, antagonist and metastasis
1) Confidence 0.07 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.82 Pain Relevance 0.20

General Comments

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