INT178087

Context Info Confidence 0.23 First Reported 2004 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.58 Pain Relevance 0.59

extracellular space (EDN1, MMP13) extracellular region (EDN1, MMP13) Golgi apparatus (MMP13) cell-cell signaling (EDN1) cytoplasm (EDN1) peptidase activity (MMP13)

Anatomy Link Frequency chondrocytes 1 EDN1 (Homo sapiens) MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 10 98.00 Osteoarthritis 70 97.08 cytokine 7 94.24 rheumatoid arthritis 6 83.76 antagonist 29 71.32 withdrawal 1 35.56 Pain 8 5.00 analgesia 2 5.00 Inflammation 2 5.00 nociceptor 2 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 72 97.08 Rheumatic Diseases 2 96.80 Metastasis 13 92.16 Rheumatoid Arthritis 6 83.76 Ovarian Cancer 23 80.40 Cancer 65 76.08 Apoptosis 44 72.92 Osteoporosis 10 70.28 Death 11 26.72 Malignant Neoplastic Disease 6 22.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, PKA activation seems to be less required for the ET-1-induced upregulation of MMP-13 and not at all necessary for the upregulation of MMP-1 since the inhibition of PKA with KT5720 does not affect the ET-1-induced overproduction of this enzyme.

ET-1-induced Positive_regulation (upregulation) of MMP-13

1) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.26 Pain Relevance 0.14

ET-1-induced stimulation of MMP-1 and MMP-13, as well as the induction of iNOS gene expression with subsequent NO overproduction by OA chondrocytes, may interfere with the proinflammatory cytokine pathways.

ET-1-induced Positive_regulation (stimulation) of MMP-13 in chondrocytes associated with osteoarthritis and cytokine

2) Confidence 0.23 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1065327 Disease Relevance 0.43 Pain Relevance 0.21

ET-1 in fact activates MMP-2, MMP-9, MMP-3, MMP-7 and MMP-13.

ET-1 Positive_regulation (activates) of MMP-13

3) Confidence 0.06 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.89 Pain Relevance 0.24

General Comments

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