INT178089

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Context Info
Confidence 0.09
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (EDNRA, PTK2) plasma membrane (EDNRA, PTK2) aging (EDNRA)
extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
EDNRA (Homo sapiens)
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
Neurotransmitter 1 75.08 Quite High
cytokine 1 48.16 Quite Low
antagonist 29 47.92 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 100.00 Very High Very High Very High
Bordatella Infection 1 100.00 Very High Very High Very High
Cancer 65 97.20 Very High Very High Very High
Ovarian Cancer 23 60.48 Quite High
Natriuresis 1 55.12 Quite High
Stress 1 52.00 Quite High
Hypoxia 9 51.28 Quite High
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ligand binding to the endothelin receptor results in activation of a pertussis toxin-insensitive G protein that stimulates phospholipase C activity and increases intracellular Ca2+ levels, activation of protein kinase C, mitogen activated protein kinase (MAPK) and p125 focal adhesion kinase (FAK) phosphorylation.
endothelin receptor Binding (binding) of Positive_regulation (activation) of FAK associated with kinase c, bordatella infection and adhesions
1) Confidence 0.09 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.74 Pain Relevance 0.09

General Comments

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