INT178091

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) plasma membrane (PTGER2)
signal transducer activity (PTGER2) cell-cell signaling (EDN1) cytoplasm (EDN1)
EDN1 (Homo sapiens)
PTGER2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 70.40 Quite High
withdrawal 1 25.28 Quite Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 23 99.84 Very High Very High Very High
Hypoxia 9 84.48 Quite High
Cancer 65 83.36 Quite High
Apoptosis 16 42.16 Quite Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low
Sarcoma 9 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Osteoporosis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ovarian carcinoma cells, ET-1 significantly increases the expression of COX-1 and -2, at mRNA and protein level, the COX-2 promoter activity and PGE2 production.
ET-1 Positive_regulation (increases) of Gene_expression (production) of PGE2 associated with ovarian cancer
1) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.74 Pain Relevance 0.04

General Comments

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