INT178092

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Context Info
Confidence 0.01
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.02
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular matrix organization (PTK2) embryo development (PTK2) microtubule organizing center (PTK2)
cytoplasm (PTK2) signal transducer activity (PTK2) cell-cell signaling (EDN3)
EDN3 (Homo sapiens)
PTK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 29 95.36 Very High Very High Very High
metalloproteinase 8 79.76 Quite High
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 14 96.72 Very High Very High Very High
Cancer 65 94.44 High High
Adhesions 4 93.36 High High
Malignant Neoplastic Disease 6 84.60 Quite High
Death 3 8.48 Low Low
Ovarian Cancer 23 5.00 Very Low Very Low Very Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Metastasis 13 5.00 Very Low Very Low Very Low
Hypoxia 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, because multiple molecular pathways, such as FAK and MAPK, elicited by ET-1 and ET-3 are triggered by the ETBR leading to the activation of all the molecular effectors involved in melanoma progression, including integrins, tumor proteases, cell-cell adhesion and communication molecules, blockade of this receptor by small molecules results into inhibition of melanoma growth in vitro and in vivo, thus offering an unprecedented opportunity of targeted therapy in this malignancy [51].



ET-3 Positive_regulation (elicited) of FAK associated with malignant neoplastic disease, cancer, skin cancer and adhesions
1) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.02 Pain Relevance 0.17

General Comments

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