INT178094

Context Info Confidence 0.06 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.95 Pain Relevance 0.24

extracellular space (EDN1, PLAU) extracellular region (EDN1, PLAU) peptidase activity (PLAU) signal transduction (PLAU) plasma membrane (PLAU) cell-cell signaling (EDN1)

EDN1 (Homo sapiens) PLAU (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 8 100.00 antagonist 29 69.04 withdrawal 1 21.24 Pain 6 5.00 analgesia 2 5.00 nociceptor 2 5.00 Pain refractory 1 5.00 cytokine 1 5.00 Central nervous system 1 5.00 Neurotransmitter 1 5.00

Disease Link Frequency Relevance Heat Ovarian Cancer 23 99.78 Cancer 65 98.40 Metastasis 13 77.84 Apoptosis 16 58.60 Malignant Neoplastic Disease 6 56.08 Reprotox - General 1 16 5.00 Skin Cancer 14 5.00 Hypoxia 9 5.00 Sarcoma 9 5.00 Breast Cancer 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the ovarian carcinoma cells, co-induction of uPA system, by the concomitant stimulation of production and secretion of uPA and uPAR, and MMPs by ET-1 resulted into the highest invasive potential of tumor cells through the Matrigel.

Positive_regulation (resulted) of ET-1 Positive_regulation (induction) of uPA associated with cancer, ovarian cancer and metalloproteinase

1) Confidence 0.06 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.95 Pain Relevance 0.24

General Comments

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