INT178096

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.01
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) plasma membrane (EDNRB)
signal transducer activity (EDNRB) cell-cell signaling (EDN1) cytoplasm (EDN1)
EDN1 (Homo sapiens)
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8 88.24 High High
antagonist 29 59.08 Quite High
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 65 97.96 Very High Very High Very High
Skin Cancer 14 90.28 High High
Adhesions 4 88.64 High High
Malignant Neoplastic Disease 6 75.32 Quite High
Death 3 60.92 Quite High
Sarcoma 9 26.96 Quite Low
Immunotherapy Of Cancer 2 13.20 Low Low
Recurrence 1 6.24 Low Low
Ovarian Cancer 23 5.00 Very Low Very Low Very Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, activation of ETBR pathway by ET-1 and ET-3 contributes to disruption of normal host-tumor interactions by downregulating the expression of E-cadherin and associated ?
ET-1 Positive_regulation (activation) of Gene_expression (pathway) of ETBR associated with cancer
1) Confidence 0.17 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.01 Pain Relevance 0.07

General Comments

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