INT1781

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2009
Negated 4
Speculated 1
Reported most in Abstract
Documents 127
Total Number 128
Disease Relevance 16.94
Pain Relevance 51.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 15
pituitary 12
brain 3
blood 2
thyroid 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 289 100.00 Very High Very High Very High
Clonidine 194 100.00 Very High Very High Very High
Somatostatin 193 100.00 Very High Very High Very High
Morphine 101 100.00 Very High Very High Very High
narcan 59 99.98 Very High Very High Very High
Paracetamol 7 99.98 Very High Very High Very High
Potency 10 99.92 Very High Very High Very High
antagonist 346 99.78 Very High Very High Very High
Opioid 59 99.76 Very High Very High Very High
Pain 20 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Body Weight 54 100.00 Very High Very High Very High
Thyroid Disease 36 100.00 Very High Very High Very High
Obesity 105 99.84 Very High Very High Very High
Rheumatoid Arthritis 137 99.70 Very High Very High Very High
Immunization 12 99.50 Very High Very High Very High
Stress 399 99.44 Very High Very High Very High
Starvation 80 99.40 Very High Very High Very High
Aids-related Complex 6 98.76 Very High Very High Very High
Hypoglycemia 13 97.84 Very High Very High Very High
Hypoxia 41 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, chronic naloxone treatment of female rats reduced basal GH levels by 64% without affecting GH pulse amplitudes or pulse frequency.
Negative_regulation (reduced) of GH associated with narcan
1) Confidence 0.59 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.67
Conflicting reports have demonstrated the alpha 2-adrenergic agonist clonidine to increase and to decrease serum GH levels in 10-day-old rats.
Negative_regulation (decrease) of GH associated with agonist and clonidine
2) Confidence 0.58 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.32
Increased plasma CS was found after 1 and 2 weeks of injections and decreased GH levels were present after 2 and 6 weeks.
Negative_regulation (decreased) of GH in plasma
3) Confidence 0.56 Published 1975 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1234768 Disease Relevance 0 Pain Relevance 0.60
Tyramine inhibited GH when injected in the PO/AHA, but not in the MBH.
Negative_regulation (inhibited) of GH in MBH
4) Confidence 0.56 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8396221 Disease Relevance 0 Pain Relevance 0.30
We conclude: (a) alpha 1 inhibition is predominant over alpha 2 stimulation of GH on or near somatostatin neurons; (b) alpha 2 stimulation predominates over alpha 1 inhibition of GH on or near GRF neurons, and (c) endogenous catecholamines in the PO/AHA have a predominantly inhibitory effect on GH secretion.
Negative_regulation (inhibition) of GH in neurons associated with catecholamine and somatostatin
5) Confidence 0.56 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8396221 Disease Relevance 0 Pain Relevance 0.30
After 2 months of diet, a significant decrease of basal GH levels and GH peak response to the 4.0 micrograms/kg rGRF dose was observed in both cafeteria-fed rat groups as compared to the control group.
Negative_regulation (decrease) of GH
6) Confidence 0.55 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2145525 Disease Relevance 0.33 Pain Relevance 0.09
After 5 months of diet, basal GH levels decreased in both cafeteria-fed groups.
Negative_regulation (decreased) of GH
7) Confidence 0.55 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2145525 Disease Relevance 0.30 Pain Relevance 0.08
Inhibition of GH in maternal separation may be mediated through altered serotonergic activity at 5-HT2A and 5-HT2C receptors.
Negative_regulation (Inhibition) of GH
8) Confidence 0.52 Published 1996 Journal Psychoneuroendocrinology Section Title Doc Link 8774064 Disease Relevance 0.09 Pain Relevance 0.46
In adult rats treated neonatally with monosodium glutamate (MSG), a neurotoxin which destroys the majority of GHRH neurons of the arcuate nucleus and reduces considerably plasma GH levels, clinical symptoms observed 14 days after inoculation of the Freund adjuvant are more marked than in AIA.
Negative_regulation (reduces) of GH in plasma associated with glutamate, freund adjuvant and arthritis
9) Confidence 0.52 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.91 Pain Relevance 0.69
In 8-week-old obese rats, a decrease of GH pituitary content and an increase of hypothalamic somatostatin (SRIF) concentration were observed.
Negative_regulation (decrease) of GH in pituitary associated with obesity and somatostatin
10) Confidence 0.51 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 2139233 Disease Relevance 1.00 Pain Relevance 0.10
The administration of chlorpromazine (CPZ, 300 microgram/100 g, i.v.), an antagonist of brain monoamines, to rats that were passively immunized with antiserum to somatostatin immediately lowered plasma GH levels and inhibited episodic GH secretion.
Negative_regulation (lowered) of GH in plasma associated with antagonist, somatostatin and monoamine
11) Confidence 0.51 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 6104306 Disease Relevance 0 Pain Relevance 0.63
Pentobarbital decreased serum GH in 5-day-old pups but increased GH in 15-, 20- and 35-day-old pups.
Negative_regulation (decreased) of GH
12) Confidence 0.51 Published 1981 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6970810 Disease Relevance 0 Pain Relevance 0.44
Idiopathic pituitary GH deficiency appears to result from neonatal disruption of hypophyseal portal vessels in the majority of patients.
Negative_regulation (deficiency) of GH in vessels
13) Confidence 0.50 Published 1991 Journal Acta Endocrinol. Section Abstract Doc Link 1676866 Disease Relevance 0.15 Pain Relevance 0
Conversely, alpha 2-adrenoceptor blockade by yohimbine (YOH, 10 mg/kg, ip) decreased baseline GH levels.
Negative_regulation (decreased) of GH
14) Confidence 0.49 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.52
T3 also antagonized the pentobarbital-induced release of GH; however, plasma B levels were not modified, and the effect on plasma GH levels was not suppressed by propranolol.
Neg (not) Negative_regulation (suppressed) of GH in plasma
15) Confidence 0.48 Published 1975 Journal Endocr Res Commun Section Abstract Doc Link 806447 Disease Relevance 0 Pain Relevance 0.08
In intact controls, baseline GH levels were in the range 40.0 to 80.0 ng/ml and were drastically reduced by urethane.
Negative_regulation (reduced) of GH
16) Confidence 0.47 Published 1976 Journal Endocrinology Section Abstract Doc Link 816640 Disease Relevance 0 Pain Relevance 0.05
This effect was not due to GH deficiency, since plasma concentrations were only slightly reduced by adrenalectomy.
Negative_regulation (deficiency) of GH in plasma
17) Confidence 0.47 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3033537 Disease Relevance 0.62 Pain Relevance 0.24
Intravenous administration of apomorphine (.03 and .1 mg/kg) had no effect on decreased GH levels, whereas clonidine (150 micrograms/kg) restored GH secretion.
Negative_regulation (decreased) of GH associated with clonidine
18) Confidence 0.47 Published 1977 Journal Endocrinology Section Abstract Doc Link 233821 Disease Relevance 0 Pain Relevance 0.23
Repeated administration of alpha-FMH (200 micrograms/rat, i.c.v., for 3 days) failed to modify basal and FK 33-824-induced GH secretion, caused a significant reduction in hypothalamic GHRH mRNA levels and left SRIF and GH mRNAs unchanged.
Negative_regulation (reduction) of GH associated with somatostatin
19) Confidence 0.47 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.29
These results suggest the following: 1) MS and PB act at a central nervous system (CNS) site to release GH; 2) TRF may act at a CNS site to inhibit MS- and PB-induced GH release; 3) somatostatin has direct pituitary effects on inhibition of GH, but a CNS site of action cannot be excluded; and 4) TRF stimulates tail motor activity in MS-treated rats.
Negative_regulation (inhibition) of GH in tail associated with somatostatin and central nervous system
20) Confidence 0.45 Published 1975 Journal Endocrinology Section Abstract Doc Link 810343 Disease Relevance 0 Pain Relevance 0.42

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