INT178100

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Context Info
Confidence 0.17
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.11
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) plasma membrane (EDNRB)
cell-cell signaling (EDN1) cytoplasm (EDN1) signal transducer activity (EDNRB)
Anatomy Link Frequency
keratinocytes 2
EDNRB (Homo sapiens)
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 8 97.08 Very High Very High Very High
antagonist 29 67.92 Quite High
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 14 99.12 Very High Very High Very High
Cancer 65 92.80 High High
Malignant Neoplastic Disease 6 84.16 Quite High
Adhesions 4 71.44 Quite High
Death 3 69.76 Quite High
Sarcoma 9 35.80 Quite Low
Immunotherapy Of Cancer 2 22.04 Low Low
Recurrence 1 15.08 Low Low
Disease 2 5.72 Low Low
Ovarian Cancer 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regards ET-1 and ET-3 by ETBR signalling induce the inactivation of the gap junctions through the phosphorylation of the Cx43, which are responsible for contact mediated regulatory control of keratinocytes.
Gene_expression (signalling) of ETBR in keratinocytes Positive_regulation (regards) of ET-1
1) Confidence 0.17 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.11 Pain Relevance 0.08

General Comments

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