INT178106

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Context Info
Confidence 0.12
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.14
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PXN) cell adhesion (PXN) plasma membrane (PXN)
cytoskeleton (PXN) cytoskeleton organization (PXN) cytoplasm (PXN)
PXN (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 64 95.48 Very High Very High Very High
metalloproteinase 8 89.32 High High
Inflammation 14 54.24 Quite High
Inflammatory response 1 22.56 Low Low
agonist 8 8.12 Low Low
withdrawal 1 6.20 Low Low
adenocard 20 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 66 97.68 Very High Very High Very High
Metastasis 13 90.64 High High
Ovarian Cancer 23 84.52 Quite High
Adhesions 10 81.08 Quite High
Malignant Neoplastic Disease 6 78.00 Quite High
Injury 2 64.08 Quite High
INFLAMMATION 12 54.24 Quite High
Stress 7 53.20 Quite High
Apoptosis 18 43.56 Quite Low
Thrombosis 2 33.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore in these cells, ET-1 stimulated FAK and paxillin phosphorylation through ETAR binding [13] which directly correlated with tumor cell migration and invasion suggesting that ETAR antagonist can inhibit cell migration and possibly other FAK-associated processes which also contributes to invasion and metastasis in this tumor [28].
Phosphorylation (phosphorylation) of paxillin associated with cancer, antagonist and metastasis
1) Confidence 0.12 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.81 Pain Relevance 0.19
These phenotypic changes (seen in both nucleotide-and matrix-mediated activation) are associated with tyrosine phosphorylation of FAK, paxillin and p130 Crk-associated substrate (p130cas) and down-stream activation of p38 MAP kinases.
Phosphorylation (phosphorylation) of paxillin
2) Confidence 0.06 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254478 Disease Relevance 0.33 Pain Relevance 0.06

General Comments

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