INT178108

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Context Info
Confidence 0.56
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.31
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP7) extracellular space (MMP7) extracellular region (MMP7)
proteinaceous extracellular matrix (MMP7)
Anatomy Link Frequency
cartilage 2
bands 2
endometrium 2
epithelial cells 1
A549 1
MMP7 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 65 100.00 Very High Very High Very High
endometriosis 276 99.20 Very High Very High Very High
fibrosis 360 99.12 Very High Very High Very High
cytokine 47 97.36 Very High Very High Very High
Inflammation 70 96.96 Very High Very High Very High
Osteoarthritis 14 95.36 Very High Very High Very High
antagonist 37 70.80 Quite High
COX2 4 67.00 Quite High
rheumatoid arthritis 2 59.76 Quite High
Analgesic 4 40.68 Quite Low
Disease Link Frequency Relevance Heat
Endometriosis 393 99.40 Very High Very High Very High
Pulmonary Fibrosis 325 99.12 Very High Very High Very High
Disease 196 97.80 Very High Very High Very High
INFLAMMATION 66 96.96 Very High Very High Very High
Arthropathy 4 96.48 Very High Very High Very High
Osteoarthritis 14 95.36 Very High Very High Very High
Wound Healing 14 94.60 High High
Metastasis 18 91.64 High High
Injury 9 87.72 High High
Severe Acute Respiratory Syndrome 116 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these results could indicate a mechanism by which osteopontin and MMP-7 are induced by aberrant activation of the WNT/?
Positive_regulation (induced) of MMP-7
1) Confidence 0.56 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.53 Pain Relevance 0.23
Thus, in fibroblasts, osteopontin increased TIMP-1 and type I collagen and inhibited MMP-1 expression, while in alveolar epithelial cells it induced MMP-7.
Positive_regulation (induced) of MMP-7 in epithelial cells
2) Confidence 0.49 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.33 Pain Relevance 0.16
g/ml osteopontin induced an increase of both the pro-MMP-7 and MMP-7 activity bands (Figure 9D).


Positive_regulation (increase) of MMP-7 in bands
3) Confidence 0.41 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.18 Pain Relevance 0.09
g/ml osteopontin induced an increase of both the pro-MMP-7 and MMP-7 activity bands (Figure 9D).


Positive_regulation (increase) of pro-MMP-7 in bands
4) Confidence 0.36 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.18 Pain Relevance 0.09
In fibroblasts, osteopontin up-regulated tissue inhibitor of metalloprotease-1 and type I collagen, and down-regulated matrix metalloprotease-1 (MMP-1) expression, while in A549 cells it caused up-regulation of MMP-7.
Positive_regulation (up-regulation) of MMP-7 in A549
5) Confidence 0.33 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1198037 Disease Relevance 0.66 Pain Relevance 0.30
ET-1 in fact activates MMP-2, MMP-9, MMP-3, MMP-7 and MMP-13.
Positive_regulation (activates) of MMP-7
6) Confidence 0.04 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.88 Pain Relevance 0.24
Furthermore, increased levels of both MMP-3 and MMP-7 were found in the eutopic endometrium of baboons with disease during the window of uterine receptivity when compared to cycle matched endometrium from control, disease-free animals [30].
Positive_regulation (increased) of MMP-7 in endometrium associated with disease
7) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 1.03 Pain Relevance 0.38
These data were independently validated by Bruner-Tran et al., [31] who demonstrated increased MMP-3 and -7 protein and mRNA levels in the secretory eutopic endometrium of women with endometriosis.
Positive_regulation (increased) of MMP-3 and -7 protein in endometrium associated with endometriosis
8) Confidence 0.04 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 1.08 Pain Relevance 0.47
For instance, we have identified the correlative change in matrix metalloproteinase MMP-7 and MMP-9 (Additional file 6): both can stimulate ?
Positive_regulation (matrix) of metalloproteinase MMP-7 associated with metalloproteinase
9) Confidence 0.03 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1262710 Disease Relevance 0.45 Pain Relevance 0.05
Specifically, we have demonstrated high levels of MMP-7 in peritoneal endometriotic lesions in baboons with experimental endometriosis [30].
Positive_regulation (levels) of MMP-7 associated with endometriosis
10) Confidence 0.03 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775067 Disease Relevance 0.91 Pain Relevance 0.36
is a major determinant of catabolic events in cartilage, which results from the stimulation of matrix metalloproteinases (MMPs) transcription and translation, which in turn digest the cartilage matrix.
Positive_regulation (stimulation) of matrix in cartilage associated with metalloproteinase
11) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.55 Pain Relevance 0.25
induced cartilage matrix breakdown and potentially, promote cartilage repair mechanisms.
Positive_regulation (induced) of matrix in cartilage
12) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1971260 Disease Relevance 0.53 Pain Relevance 0.23

General Comments

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