INT17811

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Context Info
Confidence 0.67
First Reported 1980
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 0.85
Pain Relevance 12.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
MRF 6
cortex 5
neurons 4
stomach 4
enteric nervous system 4
Vip (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 23 100.00 Very High Very High Very High
Somatostatin 21 100.00 Very High Very High Very High
substance P 18 99.90 Very High Very High Very High
Glutamate 4 99.66 Very High Very High Very High
Enkephalin 17 99.60 Very High Very High Very High
agonist 20 99.52 Very High Very High Very High
cerebral cortex 20 99.48 Very High Very High Very High
Calcitonin gene-related peptide 10 99.30 Very High Very High Very High
tetrodotoxin 34 99.26 Very High Very High Very High
amygdala 6 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 2 99.68 Very High Very High Very High
Gastric Motility Disorder 1 95.12 Very High Very High Very High
Hyperglycemia 4 91.20 High High
Peritonitis 4 78.24 Quite High
Galactorrhea 1 74.64 Quite High
Hepatotoxicity 3 69.84 Quite High
Diabetes Mellitus 41 53.76 Quite High
Injury 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under conditions of noradrenergic blockade, exposure to high K(+) (40-100 mM) produced dose-dependent increases in the VIP-LI release in a Ca(2+)-dependent manner.
Positive_regulation (increases) of Localization (release) of VIP
1) Confidence 0.67 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.12
Exposure to veratridine (3-100 microM) also induced concentration-dependent increases in VIP-LI release, an effect that was Ca(2+)-dependent and tetrodotoxin (TTX)-sensitive.
Positive_regulation (induced) of Localization (release) of VIP associated with tetrodotoxin
2) Confidence 0.67 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.13
The release of vasoactive intestinal polypeptide (VIP) induced by electrical field stimulation (EFS) of rabbit ileum was studied in vitro.
Positive_regulation (induced) of Localization (release) of VIP in ileum
3) Confidence 0.66 Published 1981 Journal Regul. Pept. Section Abstract Doc Link 7255769 Disease Relevance 0 Pain Relevance 0.08
Melatonin attenuates alpha-adrenergic-induced contractions by increasing the release of vasoactive intestinal peptide in isolated rat penile bulb.
Positive_regulation (increasing) of Localization (release) of vasoactive intestinal peptide in bulb
4) Confidence 0.57 Published 2003 Journal Urol. Res. Section Title Doc Link 12844242 Disease Relevance 0 Pain Relevance 0.29
Bilateral electrical stimulation of sciatic nerves at intensities that recruit A delta and C fibers failed to consistently increase the release of VIP-LI from the cortex in chloralose-urethane anesthetized cats but did evoke a significant increase of cortical VIP output in cats anesthetized with 1.5 and 1% halothane.
Neg (failed) Positive_regulation (increase) of Localization (release) of VIP in cortex associated with halothane and sciatic nerve
5) Confidence 0.52 Published 1985 Journal Brain Res. Section Abstract Doc Link 2982463 Disease Relevance 0 Pain Relevance 0.49
Exposure to veratridine (3-100 microM) also induced concentration-dependent increases in VIP-LI release, an effect that was Ca(2+)-dependent and tetrodotoxin (TTX)-sensitive.
Positive_regulation (increases) of Localization (release) of VIP associated with tetrodotoxin
6) Confidence 0.45 Published 2001 Journal Neurochem. Int. Section Abstract Doc Link 11137631 Disease Relevance 0 Pain Relevance 0.13
DMPP-stimulated vasoactive intestinal peptide (VIP) release in dispersed ganglia was inhibited by [Met]enkephalin and bicuculline and augmented by naloxone and GABA, implying that inhibitory opioid and stimulatory GABA neurons regulate the activity of VIP interneurons.
Positive_regulation (DMPP-stimulated) of Localization (release) of vasoactive intestinal peptide in neurons associated with gaba, narcan, enkephalin and opioid
7) Confidence 0.44 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9815026 Disease Relevance 0 Pain Relevance 0.73
DMPP-stimulated vasoactive intestinal peptide (VIP) release in dispersed ganglia was inhibited by [Met]enkephalin and bicuculline and augmented by naloxone and GABA, implying that inhibitory opioid and stimulatory GABA neurons regulate the activity of VIP interneurons.
Positive_regulation (DMPP-stimulated) of Localization (release) of VIP in neurons associated with gaba, narcan, enkephalin and opioid
8) Confidence 0.44 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9815026 Disease Relevance 0 Pain Relevance 0.73
Release of somatostatin, GABA, vasoactive intestinal peptide (VIP), and L-[3H]citrulline [coproduct and index of nitric oxide (NO) production] increased, and release of Met-enkephalin decreased, during descending relaxation.
Positive_regulation (increased) of Localization (Release) of VIP associated with gaba, somatostatin and enkephalin
9) Confidence 0.43 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943334 Disease Relevance 0 Pain Relevance 1.08
Tetrodotoxin, hexamethonium and methionine enkephalin inhibited both the induced VIP release and the secretory response.
Positive_regulation (induced) of Localization (release) of VIP associated with tetrodotoxin and enkephalin
10) Confidence 0.42 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.15 Pain Relevance 0.32
The release of both VIP and NKA was increased upon application of HCl to the cat jejunal serosa.
Positive_regulation (increased) of Localization (release) of VIP
11) Confidence 0.42 Published 1990 Journal Acta Physiol. Scand. Section Abstract Doc Link 1972607 Disease Relevance 0.15 Pain Relevance 0.31
When tetrodotoxin (1 microM) was added to the incubation medium, the veratridine- and batrachotoxin-induced release of VIP was inhibited whereas K+-induced release was unaffected.
Positive_regulation (induced) of Localization (release) of VIP associated with tetrodotoxin
12) Confidence 0.41 Published 1982 Journal Neurosci. Lett. Section Abstract Doc Link 6123097 Disease Relevance 0 Pain Relevance 0.27
Maximal stimulation obtained with 56 mMK+, 50 microM VER and 1 microM BTX corresponds to a mean 3-fold increase above the basal release of VIP in both cortex and amygdala.
Positive_regulation (increase) of Localization (release) of VIP in cortex associated with amygdala
13) Confidence 0.41 Published 1982 Journal Neurosci. Lett. Section Abstract Doc Link 6123097 Disease Relevance 0 Pain Relevance 0.25
Further, while K+-depolarization induced release of ACh and ATP from the ileal preparations, it did not lead to an increase in the release of VIP.
Positive_regulation (increase) of Localization (release) of VIP
14) Confidence 0.40 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 3685456 Disease Relevance 0 Pain Relevance 0.12
Release of VIP occurred from the entire gut: After enterectomy, the residual gut (stomach, pancreas, and proximal duodenum) released spontaneously a large amount of VIP which masked the effect of oxytocin.
Positive_regulation (occurred) of Localization (Release) of VIP in stomach
15) Confidence 0.40 Published 1980 Journal Gastroenterology Section Abstract Doc Link 7439634 Disease Relevance 0 Pain Relevance 0.09
This prompted the conclusion that the release of VIP was predominantly neurally mediated and that the chain of transmission involved a preganglionic cholinergic pathway.
Positive_regulation (mediated) of Localization (release) of VIP
16) Confidence 0.40 Published 1980 Journal Gastroenterology Section Abstract Doc Link 7439634 Disease Relevance 0 Pain Relevance 0.12
In contrast, depolarizing concentrations of K+ (50 mM) were found to cause the immediate release of TRH, but not VIP, from the same perifusion.
Positive_regulation (cause) of Localization (release) of VIP
17) Confidence 0.39 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.54
Removal of calcium ions from the superfusing fluid and substitution of cobalt (a calcium channel blocker) or EDTA (a calcium chelating agent) for calcium ions did not affect the resting release of endogenous VIP, but attenuated the increase in VIP release normally evoked by electrical stimulation of the cortical surface or MRF.
Positive_regulation (increase) of Localization (release) of VIP in MRF associated with calcium channel
18) Confidence 0.35 Published 1985 Journal Brain Res. Section Abstract Doc Link 2982463 Disease Relevance 0 Pain Relevance 0.56
NK-1 and NK-3-receptor agonists induced relaxation and stimulated vasoactive intestinal peptide (VIP) release and nitric oxide (NO) production: tetrodotoxin abolished VIP release, NO production, and relaxation, converting the response to NK-1-receptor agonists to contraction; the NO synthase inhibitor NG-nitro-L-arginine (L-NNA) abolished NO production, partly inhibited VIP release (56-64%, P < 0.01), and abolished relaxation; the VIP antagonist VIP-(10-28) partly inhibited NO production (73-74%, P < 0.001) and relaxation (56-58%, P < 0.01); and atropine augmented relaxation by 28-35% (P < 0.01).
Positive_regulation (stimulated) of Localization (release) of VIP associated with tetrodotoxin, antagonist and agonist
19) Confidence 0.34 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 7682782 Disease Relevance 0 Pain Relevance 0.41
TTX, at concentrations that prevent the increase in VIP release evoked by veratridine, greatly enhanced the surface-stimulated release but abolished the increase in VIP release evoked by MRF stimulation.
Positive_regulation (increase) of Localization (release) of VIP in MRF associated with tetrodotoxin
20) Confidence 0.31 Published 1985 Journal Brain Res. Section Abstract Doc Link 2982463 Disease Relevance 0 Pain Relevance 0.55

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