INT178118

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.06
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CB) signal transduction (PIK3CB) cell adhesion (PIK3CB)
nucleus (PIK3CB) cytoplasm (PIK3CB)
Anatomy Link Frequency
radial 3
PIK3CB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 35 96.08 Very High Very High Very High
withdrawal 1 89.40 High High
gABA 18 70.48 Quite High
cINOD 1 22.72 Low Low
diclofenac 2 22.16 Low Low
metalloproteinase 10 7.68 Low Low
cerebral cortex 30 5.00 Very Low Very Low Very Low
Somatosensory cortex 24 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 134 93.36 High High
Breast Cancer 144 92.56 High High
Cancer 279 90.16 High High
Metastasis 65 89.92 High High
Capsule Opacification 45 88.00 High High
Adhesions 9 87.84 High High
Ovarian Cancer 23 86.84 High High
Prostate Cancer 107 86.72 High High
Disseminated Intravascular Coagulation 60 76.88 Quite High
Disease 52 72.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of ligands induces dimerization of the receptor and activation of the kinase through autophosphorylation, stimulating PI3K/Akt and/or MAPK signalling, various transcription factors (such as STAT-3, c-fos and ELK-1) and enhanced production of VEGF.
Positive_regulation (stimulating) of PI3K
1) Confidence 0.32 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.65 Pain Relevance 0
Further data reveal that loss of the PTEN gene (which encodes a phosphatidylinositol phos-phatase, and therefore is a negative regulator of PI3K function) results in constitutive activation of the PI3K pathway and poor patient outcome [28].
Positive_regulation (activation) of PI3K
2) Confidence 0.32 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.07 Pain Relevance 0
In turn, activated Src kinases signal via the MAPK, PI3K, STAT3 and FAK pathways.
Positive_regulation (activated) of PI3K
3) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.23 Pain Relevance 0
One recent study has found that induction of the PDGF pathway in human LEC resulted in a PI3K/Akt pathway dependent increase in cellular migration [21].
Positive_regulation (increase) of PI3K
4) Confidence 0.14 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.51 Pain Relevance 0
It can be activated upon engagement of growth factor receptors, such as EGFR, PDGFR, INSR or IGF1R, and in turn activate downstream PLC and PI3K signaling pathways [51], [52], [66].
Positive_regulation (activate) of PI3K
5) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.33 Pain Relevance 0
By using pharmacologic blockade of specific elements of the reelin signaling pathway, we observed that accumulation of cells in the CP induced by exogenous reelin secreted by HEK cells required the activation of Dab1 (Figure 5G,J), and Pi3K (Figure 5H,J).
Positive_regulation (activation) of Pi3K
6) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.14 Pain Relevance 0.04
The full length or the central fragment of reelin realigns disrupted radial glia via VLDLR/Dab1/Pi3K activation
Positive_regulation (activation) of Pi3K in radial
7) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0
We further investigated the effects induced by reelin and found that signaling was mediated via VLDLR/Dab1/Pi3K activation while NRG1 signaling was mediated via erbB3/erbB4/Pi3K.
Positive_regulation (activation) of Pi3K
8) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0
Reelin affects the number of radial glial processes expressing BLBP via VLDLR/Dab1/Pi3K activation
Positive_regulation (activation) of Pi3K in radial
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Together, these results indicate that NRG1 via activation of erbB3/erbB4 receptors and Pi3K induces a realignment of vimentin+ radial glia (see also Figure 8).


Positive_regulation (activation) of Pi3K in radial
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Activation of ApoER2, Dab1, and PI3K but not VLDLR and GSK3?
Positive_regulation (Activation) of PI3K
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0
Further analysis of the survival pathway demonstrated that ET-1 stimulated Akt activation dependent on PI3-K.
Positive_regulation (activation) of PI3-K
12) Confidence 0.01 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.92 Pain Relevance 0.16

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