INT178127

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Context Info
Confidence 0.51
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.24
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (EDNRB) signal transducer activity (EDNRB)
Anatomy Link Frequency
smooth muscle cells 4
endothelial cells 2
smooth muscle 2
EDNRB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 8 99.88 Very High Very High Very High
antagonist 199 93.28 High High
Catecholamine 6 54.16 Quite High
agonist 4 48.00 Quite Low
Multiple sclerosis 2 30.96 Quite Low
rheumatoid arthritis 2 29.36 Quite Low
Fibrositis 1 27.60 Quite Low
headache 6 13.00 Low Low
ischemia 18 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 43 99.88 Very High Very High Very High
Cv General 3 Under Development 6 99.88 Very High Very High Very High
Breast Cancer 8 99.84 Very High Very High Very High
Increased Venous Pressure Under Development 135 99.64 Very High Very High Very High
Pulmonary Hypertension 267 99.60 Very High Very High Very High
Cancer 90 99.32 Very High Very High Very High
Eye Disease 1 91.76 High High
Coronary Heart Disease 4 90.96 High High
Ovarian Cancer 23 90.16 High High
Low Tension Glaucoma 17 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been demonstrated in both rat and monkey models of sub-arachnoid hemorrhage that increased smooth muscle cell ETB receptor expression induces vasospasm of cerebral vessels (Hino et al 1996; Hansen-Schwartz et al 2003).
Positive_regulation (increased) of Gene_expression (expression) of ETB in smooth muscle cell associated with cva and increased venous pressure under development
1) Confidence 0.51 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 0.63 Pain Relevance 0.08
The endothelin-B (ETB) receptor is expressed in primary and metastatic malignant melanoma, and increased expression of ETB correlates with tumor progression in malignant melanoma [15].
Positive_regulation (increased) of Gene_expression (expression) of ETB associated with cancer and skin cancer
2) Confidence 0.49 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2856553 Disease Relevance 0.93 Pain Relevance 0.04
Increased expression of ETB in pulmonary vascular endothelial cells should enhance ET-1-mediated release of NO and prostacyclin while improving clearance of ET-1 from the circulation (de Nucci et al 1988), whereas increased expression of ETB in pulmonary vascular smooth muscle cells would be expected to increase vasoconstriction and perhaps worsen medial thickening.
Positive_regulation (increased) of Gene_expression (expression) of ETB in smooth muscle cells associated with increased venous pressure under development
3) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.55 Pain Relevance 0.13
Langleben et al found that most PAH patients have intact endothelial ETB-mediated clearance, despite a reduced microvascular surface area from vascular remodeling, suggesting that increased expression of ETB is needed to maintain normal endothelin clearance (Langleben et al 2006).
Positive_regulation (increased) of Gene_expression (expression) of ETB associated with pulmonary hypertension
4) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.45 Pain Relevance 0.13
Increased expression of ETB in pulmonary vascular endothelial cells should enhance ET-1-mediated release of NO and prostacyclin while improving clearance of ET-1 from the circulation (de Nucci et al 1988), whereas increased expression of ETB in pulmonary vascular smooth muscle cells would be expected to increase vasoconstriction and perhaps worsen medial thickening.
Positive_regulation (Increased) of Gene_expression (expression) of ETB in endothelial cells associated with increased venous pressure under development
5) Confidence 0.40 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.57 Pain Relevance 0.13
Two studies have demonstrated increased pulmonary vascular smooth muscle expression of ETB in human PAH (Bauer et al 2002; Davie et al 2002).
Positive_regulation (increased) of Gene_expression (expression) of ETB in smooth muscle associated with pulmonary hypertension
6) Confidence 0.29 Published 2008 Journal Drug design, development and therapy Section Body Doc Link PMC2761178 Disease Relevance 0.55 Pain Relevance 0.16
ET-1 and its receptors, ETAR and ETBR, are overexpressed in breast carcinomas.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ETBR associated with breast cancer
7) Confidence 0.29 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 1.54 Pain Relevance 0.10

General Comments

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