INT17813

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Context Info
Confidence 0.36
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 12.23
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Hdl2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 99.42 Very High Very High Very High
peptic ulcer disease 1 98.62 Very High Very High Very High
agonist 3 96.44 Very High Very High Very High
Angina 11 90.72 High High
Restless leg syndrome 6 88.60 High High
abdominal pain 1 77.28 Quite High
Pain 3 75.00 Quite High
alcohol 4 23.92 Low Low
Analgesic 1 20.24 Low Low
Inflammation 1 17.04 Low Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 936 100.00 Very High Very High Very High
Disease 7 98.62 Very High Very High Very High
Ulcers 1 98.46 Very High Very High Very High
Coronary Artery Disease 88 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 49 96.48 Very High Very High Very High
Hyperlipoproteinemia Type Ii 4 94.68 High High
Obesity 25 94.56 High High
Hyperlipidemia 27 91.52 High High
Cv General 3 Under Development 8 90.72 High High
Heart Disease 2 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reduction of HDL lipids was attributed to both the HDL2 and HDL3 fractions.
Positive_regulation (attributed) of HDL2 associated with disorder of lipid metabolism
1) Confidence 0.36 Published 1986 Journal Atherosclerosis Section Abstract Doc Link 3964340 Disease Relevance 1.04 Pain Relevance 0.08
Both HDL3 and HDL2 subfractions were increased by cilostazol; however, the greatest percentage increase was observed in HDL2.
Positive_regulation (increased) of HDL2
2) Confidence 0.32 Published 1998 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9848888 Disease Relevance 0.91 Pain Relevance 0.39
Studies show that patients with peptic ulcer disease treated with the H2-receptor antagonist cimetidine show significant elevations in their HDL, HDL2, and HDL3 profiles.
Positive_regulation (elevations) of HDL2 associated with antagonist, peptic ulcer disease, disease and disorder of lipid metabolism
3) Confidence 0.25 Published 1987 Journal Pharmacotherapy Section Abstract Doc Link 2895456 Disease Relevance 1.14 Pain Relevance 0.19
There was a slight reduction in low-density lipoprotein cholesterol with an increase in HDL2, a subclass of high-density lipoprotein (HDL) cholesterol, consistent with an oestrogen-agonist effect.
Positive_regulation (increase) of HDL2 associated with agonist and disorder of lipid metabolism
4) Confidence 0.20 Published 1988 Journal J. Endocrinol. Section Abstract Doc Link 3199064 Disease Relevance 0.40 Pain Relevance 0.12
1-HDL and HDL3a were significantly lower, while the concentrations of HDL2a and HDL2b were significantly higher for subjects in the LDL-C/HDL-C < 3.5 group, compared with their counterparts in the LDL-C/HDL-C ?
Positive_regulation (concentrations) of HDL2b associated with disorder of lipid metabolism
5) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 2.28 Pain Relevance 0
The concerted action of CETP and HL converts larger HDL2 into smaller HDL3 and releases lipid-free apoA-I and/or pre?
Positive_regulation (larger) of HDL2
6) Confidence 0.17 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 1.36 Pain Relevance 0
There was a corresponding increase in HDL2/HDL3 ratio.
Positive_regulation (increase) of HDL2
7) Confidence 0.17 Published 1987 Journal Clin. Sci. Section Abstract Doc Link 3581681 Disease Relevance 0.17 Pain Relevance 0.08
1-HDL decreased significantly but HDL2b increased significantly in the corresponding middle HDL-C (1.03-1.52 mmol/L) and high HDL-C (?
Positive_regulation (increased) of HDL2b associated with disorder of lipid metabolism
8) Confidence 0.16 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2920871 Disease Relevance 2.04 Pain Relevance 0
polymorphism and the increase in HDL2 cholesterol [56].
Positive_regulation (increase) of HDL2
9) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.51 Pain Relevance 0
Other studies have demonstrated increases in the HDL2 subfraction with NiaspanĀ® given either as monotherapy (Knopp et al 1998; Goldberg et al 2000) or in combination with a statin (Van et al 2002; Bays and McGovern 2003).


Positive_regulation (increases) of HDL2
10) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.65 Pain Relevance 0
demonstrated a 50% increase in HDL2 cholesterol compared to PPARA Leu162 allele homozygotes who only had a 5.5% increase (P = .03) [56].
Positive_regulation (increase) of HDL2
11) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2288645 Disease Relevance 0.44 Pain Relevance 0
In this group also a 9% increase of HLD-cholesterol, mainly HDL-2 concentration, was found.
Positive_regulation (increase) of HDL-2 associated with disorder of lipid metabolism
12) Confidence 0.02 Published 1991 Journal Kardiol Pol Section Abstract Doc Link 1942761 Disease Relevance 0.58 Pain Relevance 0.08
A detailed analysis of ultracentrifugal lipoprotein profiles, hydroperoxide concentrations in LDL, and cholesterol-accepting properties of HDL in a small number of Lipostabil- and nicotinic acid-treated patients revealed favorable shifts in the lipoprotein profile, significant (p < .05) reductions of LDL hydroperoxides, and favorable increases of the most antiatherogenic HDL2b subfraction only in the Lipostabil-treated group.
Positive_regulation (increases) of HDL2b associated with disorder of lipid metabolism
13) Confidence 0.02 Published 1995 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 8850382 Disease Relevance 0.63 Pain Relevance 0.09

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