INT178132

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJA1) Golgi apparatus (GJA1) endoplasmic reticulum (GJA1)
cell-cell signaling (GJA1) cytoplasm (GJA1) signal transducer activity (GJA1)
GJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 35 75.96 Quite High
metalloproteinase 8 59.40 Quite High
Dismenorea 5 24.96 Low Low
Pain 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 23 98.76 Very High Very High Very High
Cancer 65 85.52 High High
Malignant Neoplastic Disease 6 82.40 Quite High
Metastasis 13 80.80 Quite High
Osteoporosis 8 38.48 Quite Low
Dysmenorrhea 5 24.96 Low Low
Apoptosis 16 13.64 Low Low
Targeted Disruption 1 13.32 Low Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GJA1 (connexin 43) is one of the main structural proteins in myometrial gap junctions; its expression is stimulated by oestradiol and inhibited by progesterone [34].
Negative_regulation (inhibited) of Gene_expression (expression) of GJA1
1) Confidence 0.35 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
Defects in intercellular communication, including reduced or inappropriate expression of Cx43 has emerged as key factors in ovarian carcinoma progression.
Negative_regulation (reduced) of Gene_expression (expression) of Cx43 associated with ovarian cancer
2) Confidence 0.13 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.84 Pain Relevance 0.07

General Comments

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