INT178141

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.89
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (EDN1, Timp1) extracellular space (EDN1) proteinaceous extracellular matrix (Timp1)
cell-cell signaling (EDN1) cytoplasm (EDN1)
Anatomy Link Frequency
extracellular matrix 1
EDN1 (Homo sapiens)
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 8 99.96 Very High Very High Very High
antagonist 29 67.68 Quite High
withdrawal 1 31.92 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
nociceptor 2 5.00 Very Low Very Low Very Low
Pain refractory 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ovarian Cancer 23 91.04 High High
Metastasis 13 88.52 High High
Cancer 65 75.52 Quite High
Apoptosis 16 69.28 Quite High
Malignant Neoplastic Disease 6 34.80 Quite Low
Reprotox - General 1 16 5.00 Very Low Very Low Very Low
Skin Cancer 14 5.00 Very Low Very Low Very Low
Hypoxia 9 5.00 Very Low Very Low Very Low
Sarcoma 9 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to soluble MMPs, ET-1 enhanced the activation of MT1-MMP and the secretion of tissue inibitor of MMP (TIMP-1 and -2) increasing the net MMP/TIMP balance and the gelatinolytic capacity that results in rapid degradation of extracellular matrix (ECM).
ET-1 Positive_regulation (increasing) of TIMP in extracellular matrix associated with metalloproteinase
1) Confidence 0.30 Published 2004 Journal J Transl Med Section Body Doc Link PMC436068 Disease Relevance 0.89 Pain Relevance 0.24

General Comments

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