| Therefore, it was proposed that validation of possible immunological targets for clinical use should depend on
Discriminating the cell types expressing the antigen on the basis of the morphological visualization of all of the parts making up the organ under investigation;
Discriminating the antigen's sub-cellular localization (nucleus, cytoplasm and plasma lemma);
Mapping antigen expression in all of the organs making up the living organism;
Estimating the percentage of normal cells and their neoplastic counterparts expressing the antigen;
Evaluating the dynamics of antigen expression at the level of the cell cycle, the physiological status of the organism and the process of aging.