INT178175

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 20
Disease Relevance 13.05
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 20
dendritic cells 6
lymphocytes 4
lungs 2
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 133 95.88 Very High Very High Very High
Potency 2 86.00 High High
Inflammation 67 84.48 Quite High
agonist 10 79.12 Quite High
rheumatoid arthritis 1 67.20 Quite High
Crohn's disease 27 64.64 Quite High
abdominal pain 1 51.68 Quite High
tolerance 8 29.60 Quite Low
antagonist 8 27.92 Quite Low
Inflammatory response 4 24.88 Low Low
Disease Link Frequency Relevance Heat
Cancer 673 100.00 Very High Very High Very High
Death 54 100.00 Very High Very High Very High
Infection 536 99.72 Very High Very High Very High
Respiratory Syncytial Virus 320 99.24 Very High Very High Very High
Sprains And Strains 141 98.68 Very High Very High Very High
Metastasis 252 98.20 Very High Very High Very High
Leukemia 7 98.04 Very High Very High Very High
Colitis 101 98.00 Very High Very High Very High
Immunization 54 96.36 Very High Very High Very High
Immune System Diseases 3 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Positive_regulation (induced) of Gene_expression (expression) of CD8 in T cells associated with immunization
1) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.16 Pain Relevance 0.08
Using DNA microarray analysis, Keino et al[17] compared patterns of gene expression in regulatory OT-1 CD8+T cells generated in vitro with those from nonregulatory OT-1 CD8+T cells.
Positive_regulation (generated) of Gene_expression (expression) of CD8 in T cells
2) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.18 Pain Relevance 0
The 667 mAb enhances the virus-specific CD8+ T-cell response
Positive_regulation (enhances) of Gene_expression (response) of CD8 in T-cell
3) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.52 Pain Relevance 0
Induction of CD8+ T cell responses p.i. with IAV IND/05 (H5N1)
Positive_regulation (Induction) of Gene_expression (responses) of CD8 in T cell
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678248 Disease Relevance 0.32 Pain Relevance 0
In this report, we initially propose a crucial role for IL-6 in SP of naive CD8+ T cells for inducing flora-specific colitogenic IL-17–producing CD8+ T (Tc17) cells.
Positive_regulation (inducing) of Gene_expression (producing) of CD8 in T cells
5) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.92 Pain Relevance 0.15
CD11c+CD8+ or CD11c-CD8+ cells isolated by FACSDiva (Becton Dickinson) from lungs harvested on dpi 8, were adoptively transferred (2.5 × 105 cells per recipient) by intra-tracheal application 1 hour after RSV infection of recipient mice.
Positive_regulation (transferred) of Gene_expression (transferred) of CD8 in lungs associated with infection and respiratory syncytial virus
6) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.48 Pain Relevance 0
Activation markers are expressed differentially on CD11c+ CD8+ and CD11c- CD8+ T cells
Positive_regulation (differentially) of Gene_expression (expressed) of CD8 in T cells
7) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.79 Pain Relevance 0.10
Two different protein-based vaccine approaches were able to induce a WT-1 specific HLA-A2 – restricted CD8+ T cell response, high levels of antigen specific IFN-?
Positive_regulation (levels) of Gene_expression (response) of CD8 in T cell
8) Confidence 0.14 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.54 Pain Relevance 0.04
As the result, a proportion of CD3int CD4high CD8- lymphocytes markedly increased in lethal-infection with the WR strain (23.5%) compared to uninfected controls (4.4%) at 5 days post-infection (Fig. 5D).
Positive_regulation (increased) of Gene_expression (proportion) of CD8 in lymphocytes associated with sprains and strains and infection
9) Confidence 0.14 Published 2007 Journal Virol J Section Body Doc Link PMC1810241 Disease Relevance 1.14 Pain Relevance 0
However, in our experimental conditions, LT(R192G) triggered an increased CD8+ lymphocytic infiltration of the airways upon virus challenge.
Positive_regulation (increased) of Gene_expression (infiltration) of CD8
10) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.97 Pain Relevance 0.04
Nasal vaccination with N SRS followed by RSV challenge results in the presence of activated CD4+ and CD8+ lymphocytes in airways
Positive_regulation (activated) of Gene_expression (lymphocytes) of CD8 in lymphocytes associated with respiratory syncytial virus
11) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0.33 Pain Relevance 0.08
In addition, the number of CD8+ T cells and dendritic cells is significantly increased in inoculated murine mammary tumor cells stably transfected with VEGF-C siRNA, suggesting that VEGF-C modulates the immune response [28].
Positive_regulation (transfected) of Gene_expression (transfected) of CD8 in dendritic cells associated with cancer
12) Confidence 0.08 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.12 Pain Relevance 0
In addition, the number of CD8+ T cells and dendritic cells is significantly increased in inoculated murine mammary tumor cells stably transfected with VEGF-C siRNA, suggesting that VEGF-C modulates the immune response [28].
Positive_regulation (increased) of Gene_expression (transfected) of CD8 in dendritic cells associated with cancer
13) Confidence 0.08 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.12 Pain Relevance 0
These data indicate that the loss of M2 during MHV68 infection specifically enhanced the MHV68-specific CD8+ T cell response, despite a significant decrease in viral latency and reactivation (see Figure 6D).
Positive_regulation (enhanced) of Gene_expression (response) of CD8 in T cell associated with infection
14) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.24 Pain Relevance 0
This response is enhanced or maintained by high numbers of MLN and PP CD8?
Positive_regulation (numbers) of Gene_expression (numbers) of CD8
15) Confidence 0.05 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.89 Pain Relevance 0.11
The proportion of CD3+, CD4+, and CD8+ T cells tended to increase slightly over the assay period, but the differences were not significant.
Positive_regulation (increase) of Gene_expression (proportion) of CD8 in T cells
16) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2596084 Disease Relevance 0 Pain Relevance 0.07
In the intestinal PP, a third subset of CD11c+ DCs distinct from lymphoid and myeloid phenotypes, has been characterized which does not express either high levels of CD11b or CD8?
Neg (not) Positive_regulation (levels) of Neg (not) Gene_expression (express) of CD8
17) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2776531 Disease Relevance 0 Pain Relevance 0.04
Blockade of activated T CD8 death increased IFN-?
Positive_regulation (activated) of Gene_expression (death) of CD8 associated with death
18) Confidence 0.03 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.07 Pain Relevance 0.07
In addition, the number of CD8+ T cells and dendritic cells is significantly increased in inoculated murine mammary tumor cells stably transfected with VEGF-C siRNA, suggesting that VEGF-C modulates the immune response [28].
Positive_regulation (transfected) of in T cells Gene_expression (transfected) of CD8 in dendritic cells associated with cancer
19) Confidence 0.03 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.12 Pain Relevance 0
In addition, the number of CD8+ T cells and dendritic cells is significantly increased in inoculated murine mammary tumor cells stably transfected with VEGF-C siRNA, suggesting that VEGF-C modulates the immune response [28].
Positive_regulation (increased) of in T cells Gene_expression (transfected) of CD8 in dendritic cells associated with cancer
20) Confidence 0.03 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.12 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox