INT17818

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Context Info
Confidence 0.56
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 12.96
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
pituitary 2
adipose tissue 1
posterior pituitary 1
neutrophil 1
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 55 100.00 Very High Very High Very High
agonist 55 100.00 Very High Very High Very High
beta blocker 4 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
ischemia 16 99.42 Very High Very High Very High
Dopamine 3 97.84 Very High Very High Very High
rheumatoid arthritis 5 96.84 Very High Very High Very High
Inflammation 33 95.72 Very High Very High Very High
Pain 7 94.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 32 100.00 Very High Very High Very High
Pituitary Cancer 16 99.60 Very High Very High Very High
Obesity 38 99.52 Very High Very High Very High
Hypertension 46 99.44 Very High Very High Very High
Cv Unclassified Under Development 5 99.42 Very High Very High Very High
Cancer 244 99.20 Very High Very High Very High
Cv General 4 Under Development 15 98.84 Very High Very High Very High
Metastasis 54 98.20 Very High Very High Very High
Increased Venous Pressure Under Development 13 97.98 Very High Very High Very High
Stress 17 97.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the literature AT2-receptor mediated actions on vascular tone have been reported in terms of vasodilation and decrease of arterial pressure and particularly so during pathological conditions with increased AT2 receptor expression [2,17] eg in hypertensive states [18].
Gene_expression (expression) of AT2 associated with hypertension and increased venous pressure under development
1) Confidence 0.56 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.20 Pain Relevance 0.12
Our current data supports this hypothesis as both RNA and protein expression of the AT2 receptor were detected in the jejunal wall of the pig.
Gene_expression (expression) of AT2
2) Confidence 0.56 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.16 Pain Relevance 0.09
AT1 and AT2 receptor expression
Gene_expression (expression) of AT2
3) Confidence 0.49 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0 Pain Relevance 0
rtPCR AT1 and AT2 receptors
Gene_expression (receptors) of AT2
4) Confidence 0.49 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0 Pain Relevance 0
Western blot and rtPCR recognised expression of the AT1 and AT2 receptors in jejunal tissue.


Gene_expression (expression) of AT2
5) Confidence 0.44 Published 2003 Journal BMC Pharmacol Section Abstract Doc Link PMC153509 Disease Relevance 0 Pain Relevance 0.16
Biopsies for studying AT1 and AT2 receptor expression were obtained in a subset of 11 animals.
Gene_expression (expression) of AT2
6) Confidence 0.44 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.25 Pain Relevance 0.30
We explored the effects of direct renal interstitial stimulation of dopamine D(1)-like receptors with fenoldopam, a selective D(1)-like receptor agonist, on renal sodium excretion and angiotensin type-2 (AT(2)) receptor expression and cellular distribution in rats on a high-sodium intake.
Gene_expression (expression) of angiotensin type-2 associated with dopamine and agonist
7) Confidence 0.42 Published 2007 Journal Hypertension Section Abstract Doc Link 17116755 Disease Relevance 0.07 Pain Relevance 0.14
The high dose enhanced the expression of angiotensinogen and angiotensin II receptor type 2 mRNA and suppressed the overexpression of transforming growth factor-beta1 mRNA.
Gene_expression (expression) of angiotensin II receptor type 2 mRNA
8) Confidence 0.38 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.74 Pain Relevance 0.65
Versus other angiotensin II receptor antagonists
Gene_expression (antagonists) of angiotensin II receptor associated with antagonist
9) Confidence 0.31 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994016 Disease Relevance 0.59 Pain Relevance 0.14
Both the AT1R and AT2R stimulate VEGF secretion by rat pituitary tumour cells [13] and the AT2R is highly expressed in intratumoural blood vessels of human pituitary adenomas[12].
Gene_expression (expressed) of AT2R in pituitary associated with pituitary cancer
10) Confidence 0.30 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.33 Pain Relevance 0.07
AT2R expression is low in most adult tissues [37], but is frequently up-regulated in patients with gastric cancer [38].
Gene_expression (expression) of AT2R associated with stomach cancer
11) Confidence 0.30 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.00 Pain Relevance 0
The AT2 receptor expression was up-regulated by a 9-hour period, and then decreased between 12- and 24-hour periods.
Gene_expression (expression) of AT2 receptor
12) Confidence 0.24 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17197045 Disease Relevance 0.54 Pain Relevance 0.35
AT2R expression has been documented in blood vessels of human pituitary adenomas[12] and both the AT1R and AT2R stimulate vascular endothelial growth factor (VEGF) secretion by rat pituitary tumour cells [13].
Gene_expression (expression) of AT2R in pituitary associated with pituitary cancer
13) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.32 Pain Relevance 0.10
The most frequently used antihypertensives were angiotensin-converting enzyme inhibitors (49.6%), calcium antagonists (24.8%), beta blockers (11.7%), angiotensin II-receptor blockers (5.5%), and alpha blockers (0.9%).
Gene_expression (inhibitors) of angiotensin II-receptor associated with beta blocker and antagonist
14) Confidence 0.23 Published 2001 Journal Adv Ther Section Abstract Doc Link 11571824 Disease Relevance 0.57 Pain Relevance 0.17
The AT2R agonist CGP42112A (Sigma-Aldrich, C160) at 0.6 ?
Gene_expression (agonist) of AT2R associated with agonist
15) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.02 Pain Relevance 0.08
Recent studies have shown increased expression of angiotensin II-forming enzymes in adipose tissue, and increased activity of the renin-angiotensin system has been implicated in the development of insulin resistance and type 2 diabetes [3].
Gene_expression (expression) of angiotensin II-forming in adipose tissue associated with diabetes mellitus, obesity and insulin resistance
16) Confidence 0.22 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.57 Pain Relevance 0.10
Our group has previously shown that in addition to an ischemia-induced endothelin receptor upregulation, there is an alteration in the vascular angiotensin II receptor response after experimental cerebral ischemia [27].
Gene_expression (upregulation) of angiotensin II receptor associated with cv general 4 under development and ischemia
17) Confidence 0.21 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.69 Pain Relevance 0.32
Much attention is paid to perspectives of ACE inhibitors, angiotensin II receptor blockers, statins, TNFalpha inhibitors in prevention of cardiovascular complication in RA
Gene_expression (blockers) of angiotensin II receptor associated with rheumatoid arthritis
18) Confidence 0.11 Published 2009 Journal Ter. Arkh. Section Abstract Doc Link 19537595 Disease Relevance 1.07 Pain Relevance 0.35
The eotaxin levels were significantly higher in DMTI-II-injected rats compared with control animals.
Gene_expression (higher) of DMTI-II
19) Confidence 0.11 Published 2009 Journal Toxicon Section Abstract Doc Link 19103216 Disease Relevance 0.11 Pain Relevance 0.28
The peritoneal neutrophil influx initiated at 4h, achieving maximal responses at 16 h after DMTI-II injection (16- and 22-fold increase, respectively).
Gene_expression (injection) of DMTI-II in neutrophil
20) Confidence 0.11 Published 2009 Journal Toxicon Section Abstract Doc Link 19103216 Disease Relevance 0.32 Pain Relevance 0.30

General Comments

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