INT178182

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Context Info
Confidence 0.33
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.13
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
body 2
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 12 99.96 Very High Very High Very High
isoflurane 5 99.90 Very High Very High Very High
cytokine 58 81.92 Quite High
anesthesia 4 77.04 Quite High
Inflammation 89 53.36 Quite High
iatrogenic 5 44.72 Quite Low
antagonist 16 34.40 Quite Low
agonist 36 31.68 Quite Low
chemokine 5 18.84 Low Low
adenocard 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 93 99.96 Very High Very High Very High
Body Weight 7 99.52 Very High Very High Very High
Bronchiolo-alveolar Adenocarcinoma 1 92.68 High High
Unconsciousness 1 90.48 High High
Lung Cancer 3 89.00 High High
Cancer 203 81.80 Quite High
Endotoxemia 6 79.12 Quite High
Prostate Cancer 6 78.20 Quite High
Myeloid Leukemia 1 77.40 Quite High
Multiple Myeloma 4 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, this molecule could act through 2 distinct mechanisms: on one hand, LPS binding and decreased inflammatory response, and, on the other hand improved bacterial phagocytosis and complement mediated killing [24].
Negative_regulation (decreased) of LPS Binding (binding) of associated with inflammatory response
1) Confidence 0.33 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.29 Pain Relevance 0.05
In summary, the complex RP105-MD1 interacts directly with the TLR4 signalling complex, preventing its ability to bind LPS.
Negative_regulation (preventing) of LPS Binding (bind) of
2) Confidence 0.32 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.14 Pain Relevance 0
DCwere matured with a combination of LPS, CD40L and IFN-?
Negative_regulation (matured) of LPS Binding (combination) of
3) Confidence 0.19 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.19 Pain Relevance 0.04
After 1 h, mice were anesthetized again with isoflurane and injected with LPS at a dose of 4 mg/kg body weight in a total volume of 50 ?
Negative_regulation (dose) of LPS Binding (injected) of in body associated with body weight and isoflurane
4) Confidence 0.13 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.51 Pain Relevance 0.29

General Comments

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