INT178183

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Context Info
Confidence 0.32
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 7.80
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 8
lymph nodes 1
spleens 1
lungs 1
helper T cell 1
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 42 100.00 Very High Very High Very High
Inflammation 102 98.68 Very High Very High Very High
Central nervous system 86 95.60 Very High Very High Very High
Multiple sclerosis 6 90.48 High High
Inflammatory response 17 89.48 High High
cytokine 98 86.16 High High
Inflammatory mediators 4 83.24 Quite High
transdermal 14 74.36 Quite High
anesthesia 14 52.44 Quite High
glial activation 2 49.16 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 10 100.00 Very High Very High Very High
Weight Loss 8 100.00 Very High Very High Very High
Respiratory Syncytial Virus 112 99.04 Very High Very High Very High
INFLAMMATION 117 98.68 Very High Very High Very High
Immunotherapy Of Cancer 16 98.24 Very High Very High Very High
Skin Cancer 33 96.64 Very High Very High Very High
Autoimmune Disease 36 96.60 Very High Very High Very High
Viral Hemorrhagic Fevers 4 95.76 Very High Very High Very High
Hypersensitivity Pneumonitis 70 93.68 High High
Cancer 410 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that only CD8+CD94+T cells from ACAID mice profoundly inhibited the proliferation of responder cells, CD8+CD94-T cells from ACAID mice as well as immunized mice showed no suppressive activity.
CD8 Binding (immunized) of in T cells
1) Confidence 0.32 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.09 Pain Relevance 0
What is the specific marker for CD8+Treg?
CD8 Binding (marker) of
2) Confidence 0.32 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
The resulting values confirmed the previous finding that tetramer+CD8+ CTL from the lungs of RSV-infected mice are impaired in IFN?
CD8 Spec (finding) Binding (finding) of in lungs associated with respiratory syncytial virus
3) Confidence 0.23 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 0.69 Pain Relevance 0
For HNT cells, this was performed by gating on CD8?
CD8 Binding (gating) of
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0 Pain Relevance 0
Thus, overcoming cross-tolerance requires the cooperation of memory-like CD8+ and CD4+ T cells.
CD8 Binding (cross) of in T cells associated with tolerance
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.38 Pain Relevance 0.12
Antibodies were purchased from BD Pharmingen or eBioscience and included monoclonal antibodies recognizing mouse CD4 (RM4-5), CD8?
CD8 Binding (recognizing) of
6) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0.04
Preferential recruitment of CD11c+ CD8+T cells to the lung
CD8 Binding (recruitment) of in T cells
7) Confidence 0.14 Published 2005 Journal Respir Res Section Body Doc Link PMC1184101 Disease Relevance 0.90 Pain Relevance 0
Therefore, the percentages of CD4+ and CD8+ T cells in the BALF from B6 and Fc?
CD8 Binding (percentages) of in T cells
8) Confidence 0.11 Published 2010 Journal Immune Network Section Body Doc Link PMC2837154 Disease Relevance 0.68 Pain Relevance 0.07
Gene based vaccines, such as viral vectors, have proved highly efficient at generation of CD8+ T cell responses, particularly in mouse models, but can be deficient at inducing a potent CD4+ helper T cell response.
CD8 Binding (generation) of in helper T cell
9) Confidence 0.11 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.21 Pain Relevance 0
His word demonstrated that TCR with high affinity for their ligand become CD4 or CD8.
CD8 Binding (affinity) of
10) Confidence 0.10 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.95 Pain Relevance 0
were similar in both spleens and lymph nodes of IM and MN groups whereas the CD8+ associated IFN-?
CD8 Binding (associated) of in spleens
11) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.21 Pain Relevance 0.04
Notch signaling regulates CD4/CD8 T cell lineage commitment, whereas PS/?
CD8 Binding (commitment) of in T cell
12) Confidence 0.07 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.85 Pain Relevance 0.12
With the use of two-photon microscopy, CD8+ T cell–DC interactions were observed in the range of hours [25,37].
CD8 Binding (interactions) of in T cell
13) Confidence 0.06 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0
To study the interaction between CD8 T cells and the NVU under neuro-inflammatory conditions, our laboratory has developed a novel mouse model of CNS vascular permeability using a variation of the Theiler's murine encephalomyelitis virus (TMEV) model commonly used to study multiple sclerosis [20]–[22].
CD8 Binding (interaction) of in T cells associated with multiple sclerosis, inflammation, encephalitis and central nervous system
14) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516328 Disease Relevance 0.84 Pain Relevance 0.29
However, when the CD8 T cell subset was depleted in vivo from the Memphis-primed animals, significant weight loss was observed on day 5 after lethal challenge (mean percentage of original body weight: 92.3% versus 82.9% when PBS control was compared with CD8-depleted group, p?
CD8 Binding (compared) of in body associated with body weight and weight loss
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2868023 Disease Relevance 0.71 Pain Relevance 0
Similarly, staining for CD3, CD4, CD8 or B220 was always negative in the CVOs of healthy mice (Table 1).


CD8 Binding (staining) of
16) Confidence 0.06 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.25 Pain Relevance 0
Epitopes recognized by CD4+ and CD8+ T cells of surviving mice were determined as previously described [40].
CD8 Binding (recognized) of in T cells
17) Confidence 0.04 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1326218 Disease Relevance 0.80 Pain Relevance 0.08
were similar in both spleens and lymph nodes of IM and MN groups whereas the CD8+ associated IFN-?
CD8 Binding (associated) of in lymph nodes
18) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651574 Disease Relevance 0.21 Pain Relevance 0.04

General Comments

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