INT178188

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.33
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Anatomy Link Frequency
B cell 2
macrophages 1
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 83 99.90 Very High Very High Very High
cytokine 273 98.76 Very High Very High Very High
chemokine 17 86.40 High High
tolerance 20 79.60 Quite High
Inflammation 156 71.92 Quite High
Inflammatory response 12 42.72 Quite Low
sodium channel 6 36.80 Quite Low
rheumatoid arthritis 15 5.00 Very Low Very Low Very Low
Potency 13 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Influenza Virus Infection 685 99.84 Very High Very High Very High
Experimental Melanoma 1 98.64 Very High Very High Very High
Systemic Lupus Erythematosus 155 97.52 Very High Very High Very High
Syndrome 27 96.96 Very High Very High Very High
Death 25 94.52 High High
Viral Infection 45 91.44 High High
Liver Cancer 1 88.12 High High
Infection 243 86.88 High High
Hepatitis B Virus Infection 5 86.48 High High
Disease 120 83.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Receptor-mediated entry of whole inactivated influenza vaccines into the target cells can deliver their single-stranded RNA molecules, an activator for toll-like receptor-7 (TLR7), resulting in the induction of Th1 type immune responses [9], [42].
Positive_regulation (activator) of TLR7 associated with influenza virus infection
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.47 Pain Relevance 0
Receptor-mediated entry of whole inactivated influenza vaccines into the target cells can deliver their single-stranded RNA molecules, an activator for toll-like receptor-7 (TLR7), resulting in the induction of Th1 type immune responses [9], [42].
Positive_regulation (activator) of toll-like receptor-7 associated with influenza virus infection
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2745577 Disease Relevance 0.42 Pain Relevance 0
Single-stranded RNA induction of TLR7 also stimulates autophagy, a cell-autonomous innate defence mechanism for elimination of intracellular pathogens, in macrophages.
Positive_regulation (induction) of TLR7 in macrophages
3) Confidence 0.39 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.33 Pain Relevance 0.22
Stimulation of TLR7 and TLR8 appears to modulate the function of innate immunity by promoting the production of TNF-?
Positive_regulation (Stimulation) of TLR7
4) Confidence 0.37 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.98 Pain Relevance 0.29
Interestingly, emerging data support the activation of TLR7 and 8 by antiphospholipid antibodies (APL) isolated from patients with APL syndrome [32, 33], as has been also shown previously for TLR2 and 4 [34–36].
Positive_regulation (activation) of TLR7 associated with syndrome
5) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.21 Pain Relevance 0.03
Other genes occurring in tandem include Tlr7 and Tlr8, Islr1 and Islr2, Lrrc21/Pal and Lrrc22, Lrrc8b, c and d and Fshr and Lhcgr.
Positive_regulation (include) of Tlr7
6) Confidence 0.32 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2235866 Disease Relevance 0.15 Pain Relevance 0
Experimental analysis of sequential activation of TLR7, 8 and 9 in HEK293 cells demonstrated that activation of TLR9 inhibited TLR7 activation but not vice versa [207].
Positive_regulation (activation) of TLR7
7) Confidence 0.26 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.64 Pain Relevance 0.19
producing cells following exposure to a TLR7 agonist and stimulation of TLR7 results in induction of IL-6, IL-12, MIP-1?
Positive_regulation (stimulation) of TLR7 associated with agonist
8) Confidence 0.26 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.27 Pain Relevance 0.21
There are, however, some serious concerns relating to stimulation of TLR7 receptors.
Positive_regulation (stimulation) of TLR7
9) Confidence 0.26 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.79 Pain Relevance 0.29
TLR7 activation by influenza virus stimulates cytokine production [159, 167], whereas a MyD88-dependent pathway distinct from the TLR7 pathway appears to be involved in B cell responses to influenza virus [202, 203].
Positive_regulation (activation) of TLR7 in B cell associated with influenza virus infection and cytokine
10) Confidence 0.26 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.92 Pain Relevance 0.21
RIIa and reach the endosomal compartment where they activate TLR7 and TLR, respectively, leading to secretion of cytokines such as IFN-?
Positive_regulation (activate) of TLR7 associated with cytokine
11) Confidence 0.25 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2933908 Disease Relevance 0.34 Pain Relevance 0.13
induction by C- and D-type CpG ODNs in human pDCs and B cells is markedly reduced by stimulation of TLR7, without affecting IL-6 secretion or B cell proliferation [204–206].
Positive_regulation (stimulation) of TLR7 in B cell
12) Confidence 0.23 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.82 Pain Relevance 0.21

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