INT17819

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Context Info
Confidence 0.51
First Reported 1991
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 10
Total Number 15
Disease Relevance 9.33
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
liver 3
neuronal 1
nucleus accumbens 1
blood 1
plasma 1
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 23 100.00 Very High Very High Very High
antagonist 18 100.00 Very High Very High Very High
opioid receptor 12 100.00 Very High Very High Very High
Dopamine 14 99.36 Very High Very High Very High
Glutamate receptor 2 99.12 Very High Very High Very High
Migraine 10 98.64 Very High Very High Very High
Nucleus accumbens 10 98.04 Very High Very High Very High
Locus ceruleus 5 95.04 Very High Very High Very High
Neuronal excitability 2 94.92 High High
tolerance 5 93.32 High High
Disease Link Frequency Relevance Heat
Cancer 300 99.84 Very High Very High Very High
Immunotherapy Of Cancer 5 99.62 Very High Very High Very High
Injury 6 99.24 Very High Very High Very High
Metastasis 65 99.12 Very High Very High Very High
Headache 12 98.64 Very High Very High Very High
Colon Cancer 175 98.40 Very High Very High Very High
Apoptosis 105 97.76 Very High Very High Very High
Hypoxia 10 96.84 Very High Very High Very High
Pituitary Cancer 20 92.56 High High
Chronic Renal Failure 1 86.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alterations of angiotensin II Receptor levels in sutured wounds in rat skin.
Regulation (Alterations) of angiotensin II Receptor in skin associated with injury
1) Confidence 0.51 Published 1996 Journal J Invest Surg Section Title Doc Link 8981218 Disease Relevance 0.53 Pain Relevance 0.08
The AT2 receptor antagonist PD 123319 (1 micromol/l) did not affect AngII-induced contractions under either condition.
Neg (not) Regulation (affect) of AT2 receptor associated with antagonist
2) Confidence 0.22 Published 2001 Journal Pharmacology Section Abstract Doc Link 11490203 Disease Relevance 0.20 Pain Relevance 0.20
The effect of deltorphin II (50.0 nmol) was not altered by the selective delta2-opioid receptor antagonist, naltriben (1.5 nmol), which alone did not significantly affect the basal levels of dopamine.
Neg (not) Regulation (altered) of deltorphin II associated with dopamine, antagonist and opioid receptor
3) Confidence 0.15 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15102530 Disease Relevance 0 Pain Relevance 0.78
The effects of the delta2-opioid receptor agonist, deltorphin II, on extracellular levels of dopamine in the rat nucleus accumbens were investigated in awake animals by in vivo brain microdialysis.
Spec (investigated) Regulation (effects) of deltorphin II in nucleus accumbens associated with nucleus accumbens, dopamine, agonist and opioid receptor
4) Confidence 0.15 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15102530 Disease Relevance 0 Pain Relevance 0.55
The results suggested that up-regulation of A2R and altered non-NMDA glutamate receptor function induced by chronic hypobaric hypoxia may underlie, in part, the decreased LC neuronal excitability and acute hypoxia tolerance.
Regulation (regulation) of A2R in neuronal associated with neuronal excitability, hypoxia, locus ceruleus, glutamate receptor and tolerance
5) Confidence 0.14 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842765 Disease Relevance 0.53 Pain Relevance 0.71
The AT2R generally exerts actions antagonistic to the AT1R including inhibition of proliferation and angiogenesis [9,10] and promotion of apoptosis [11] and while AT1R blockade has been extensively studied in the context of cancer treatment, the potential of targeting the AT2R in cancer has not been investigated.
Regulation (targeting) of AT2R associated with cancer, apoptosis and immunotherapy of cancer
6) Confidence 0.10 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.26 Pain Relevance 0.10
Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases

Background

Regulation (Targeting) of AT2R in liver associated with metastasis
7) Confidence 0.10 Published 2010 Journal Cancer Cell Int Section Title Doc Link PMC2902462 Disease Relevance 1.17 Pain Relevance 0.04
Here we targeted the AT2R via the agonist, CGP42112A[14,15], in an orthotopic syngenic mouse model of CRC liver metastases in which we previously demonstrated inhibition of tumour growth following AT1R blockade [8].


Regulation (targeted) of AT2R in liver associated with cancer, colon cancer, agonist and metastasis
8) Confidence 0.10 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.30 Pain Relevance 0.05
Therefore, it was the aim of this study to establish the potential of targeting the AT2R to inhibit tumour growth in a model of CRC liver metastases.
Regulation (targeting) of AT2R in liver associated with cancer, colon cancer and metastasis
9) Confidence 0.10 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.17 Pain Relevance 0.07
While AT1R blockade has been extensively studied, the potential of targeting the antagonistically acting AT2R in cancer has not been investigated.
Regulation (targeting) of AT2R associated with cancer
10) Confidence 0.09 Published 2010 Journal Cancer Cell Int Section Abstract Doc Link PMC2902462 Disease Relevance 1.07 Pain Relevance 0.05
The involvement of AT1 and AT2 receptor subtypes in the response of the isolated rat uterus to angiotensin II (AngII) was studied throughout the estrous cycle.
Regulation (involvement) of AT2 receptor in uterus
11) Confidence 0.05 Published 2002 Journal Pharmacology Section Abstract Doc Link 12037380 Disease Relevance 0.05 Pain Relevance 0.10
In addition plasma concentrations of OTNP-I and OTNP-II were above the baseline.
Regulation (concentrations) of OTNP-II in plasma
12) Confidence 0.03 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.06 Pain Relevance 0.24
ARBs selectively block AT1 receptor activity with no blocking effect on the AT2 receptor.
Regulation (effect) of AT2 receptor
13) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.99 Pain Relevance 0
Clinical trials indicated that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are effective in the prophylactic treatment of migraine.
Regulation (effective) of angiotensin II receptor associated with migraine
14) Confidence 0.02 Published 2006 Journal J Hypertens Suppl Section Abstract Doc Link 16601567 Disease Relevance 0.78 Pain Relevance 0.78
Effects of the angiotensin II receptor antagonist, TCV-116, on blood pressure and the renin-angiotensin system in healthy subjects.
Regulation (Effects) of angiotensin II receptor in blood associated with antagonist
15) Confidence 0.01 Published 1994 Journal Clin Ther Section Title Doc Link 8205603 Disease Relevance 0.21 Pain Relevance 0.15

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