INT178195

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.64
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Wt1) RNA binding (Wt1) nucleus (Wt1)
intracellular (Wt1) DNA binding (Wt1) cytoplasm (Wt1)
Anatomy Link Frequency
T cells 2
cleavage 1
Wt1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 9 87.84 High High
Pain 5 54.88 Quite High
Inflammation 4 36.92 Quite Low
metalloproteinase 28 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 285 100.00 Very High Very High Very High
Targeted Disruption 8 99.12 Very High Very High Very High
Myeloid Leukemia 55 98.00 Very High Very High Very High
Lung Cancer 141 96.36 Very High Very High Very High
Malignant Neoplastic Disease 15 96.32 Very High Very High Very High
Death 7 86.72 High High
Leukemia 22 86.40 High High
Desmoplastic Small Round Cell Tumor 1 85.60 High High
Apoptosis 27 83.28 Quite High
Solid Tumor 7 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Frequency of WT1/MHC tetramer+CD8+ T cells
Localization (Frequency) of WT1 in T cells
1) Confidence 0.69 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.06 Pain Relevance 0
Collectively, these data demonstrate that TEV protease cleavage and the presence of WT1(+KTS) was not required for identification of these mRNAs.
Localization (presence) of WT1 in cleavage
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714980 Disease Relevance 0 Pain Relevance 0
Clinical efficacy of WT1 peptide vaccination
Localization (vaccination) of WT1
3) Confidence 0.60 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2860640 Disease Relevance 0.21 Pain Relevance 0.05
secretion from CD4+ T cells and significant titers of IgG1 and IgG2a WT-1-specific antibodies in HLA-A2 transgenic mouse models.
Localization (secretion) of WT-1-specific in T cells associated with targeted disruption
4) Confidence 0.17 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.49 Pain Relevance 0.04
WT1 is a tumor suppressor gene localized to chromosome 11 that is inactivated through mutation in 10% of WilmsÂ’ tumors, a pediatric malignancy of renal origin.
Localization (localized) of WT1 associated with malignant neoplastic disease and cancer
5) Confidence 0.08 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.87 Pain Relevance 0

General Comments

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