INT178196

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Context Info
Confidence 0.27
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 7.47
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfc) extracellular space (Vegfc) extracellular region (Vegfc)
Anatomy Link Frequency
FaDu 3
endothelial cells 2
epithelial cells 2
Vegfc (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 3 99.92 Very High Very High Very High
cytokine 54 99.60 Very High Very High Very High
chemokine 9 90.80 High High
Inflammation 27 85.76 High High
alcohol 9 84.04 Quite High
agonist 27 5.00 Very Low Very Low Very Low
tolerance 12 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retinoblastoma 3 99.00 Very High Very High Very High
Cancer 831 98.70 Very High Very High Very High
Pharynx Cancer 9 92.72 High High
Targeted Disruption 24 91.08 High High
Genital Human Papilloma Virus 12 86.24 High High
INFLAMMATION 30 85.76 High High
Corneal Neovascularization 9 85.20 High High
Disease 36 85.04 High High
Papillomavirus Infection 60 79.80 Quite High
Lymphatic System Cancer 3 77.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The production of VEGFc has been correlated with increased metastatic potential in HNSCC [23], and USC-HN1 has shown a statistically increased production of VEGFc compared with FaDu.
Gene_expression (production) of VEGFc in FaDu
1) Confidence 0.27 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.20 Pain Relevance 0.22
The production of VEGFc has been correlated with increased metastatic potential in HNSCC [23], and USC-HN1 has shown a statistically increased production of VEGFc compared with FaDu.
Gene_expression (production) of VEGFc in FaDu
2) Confidence 0.27 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.09 Pain Relevance 0.21
Finally, the predicted inactivation of E6 and E7 oncogenic potential was confirmed by demonstrating normal levels of both p53 and retinoblastoma proteins in human mammary epithelial cells (MEC) infected with VRP expressing mutant E6 and E7 genes.
Gene_expression (expressing) of VRP in epithelial cells associated with retinoblastoma
3) Confidence 0.23 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.18 Pain Relevance 0
Finally, the predicted inactivation of E6 and E7 oncogenic potential was confirmed by demonstrating normal levels of both p53 and retinoblastoma proteins in human mammary epithelial cells (MEC) infected with VRP expressing mutant E6 and E7 genes.
Gene_expression (infected) of VRP in epithelial cells associated with retinoblastoma
4) Confidence 0.20 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.13 Pain Relevance 0
Eradication of C3 tumors was observed in approximately 90% of mice following therapeutic VRP vaccination.
Gene_expression (vaccination) of VRP associated with cancer
5) Confidence 0.18 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 1.27 Pain Relevance 0
produced by USC-HN1 and the FaDu cell line, and no significant differences between p53, Rb, c-Kit, VEGFc, COX2, TGF-?
Gene_expression (produced) of VEGFc in FaDu associated with cox2
6) Confidence 0.15 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 1.31 Pain Relevance 0.13
VEGF-C-induced NP2 expression at both mRNA and protein levels was significantly suppressed by NP2 amiRNA in mouse lymphatic endothelial cells.
Gene_expression (expression) of VEGF-C-induced in endothelial cells
7) Confidence 0.07 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994732 Disease Relevance 0.13 Pain Relevance 0.03
Mouse lymphatic endothelial cells were transfected with the plasmid expressing artificial microRNA (amiRNA) against mouse NP2, and the down-regulation of VEGF-C-induced NP2 expression by NP2 amiRNA was evaluated by real-time PCR and western blot assays.
Gene_expression (expression) of VEGF-C-induced in endothelial cells
8) Confidence 0.07 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2994732 Disease Relevance 0.17 Pain Relevance 0.04
NP2-targeting amiRNA suppresses VEGF-C-induced NP2 expression in mouse LECs
Gene_expression (expression) of VEGF-C-induced
9) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994732 Disease Relevance 0 Pain Relevance 0

General Comments

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