INT178198

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 62
Total Number 63
Disease Relevance 39.50
Pain Relevance 7.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
synovium 8
joint 4
hematopoietic cells 3
cleavage 2
parenchymal cells 2
C3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 931 100.00 Very High Very High Very High
cytokine 275 100.00 Very High Very High Very High
rheumatoid arthritis 517 99.84 Very High Very High Very High
cva 110 97.92 Very High Very High Very High
Arthritis 881 97.76 Very High Very High Very High
ischemia 162 94.40 High High
imagery 51 93.80 High High
cerebral cortex 32 91.80 High High
Inflammatory response 129 84.00 Quite High
TRP channel 50 83.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 946 100.00 Very High Very High Very High
Cancer 284 100.00 Very High Very High Very High
Obesity 153 99.98 Very High Very High Very High
Clostridium Infection 4 99.98 Very High Very High Very High
Rheumatoid Arthritis 518 99.84 Very High Very High Very High
Renal Disease 121 99.84 Very High Very High Very High
Atherosclerotic Plaque 52 99.84 Very High Very High Very High
Myocardial Infarction 643 99.60 Very High Very High Very High
Amyloid Plaque 122 99.60 Very High Very High Very High
Colon Cancer 2 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The next question was whether C3 had to be produced by radioresistant cells locally within the joint, or whether it could be made by parenchymal cells at distant sites and transported to the joints via the circulation.
Gene_expression (produced) of C3 in parenchymal cells
1) Confidence 0.78 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.12 Pain Relevance 0.03
In short, production of C3 by leukocytes was not required for K/BxN serum–induced arthritis, even with prolonged administration of arthritogenic serum.
Gene_expression (production) of C3 in leukocytes associated with arthritis
2) Confidence 0.78 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.33 Pain Relevance 0.16
The hypothesis that local C3 production is important in RA arose from the finding that more C3 is produced in rheumatoid synovium than in osteoarthritic synovium, as determined qualitatively or quantitatively using in situ hybridization to detect messenger RNA (mRNA) for C3 (28,30).
Gene_expression (production) of C3 in synovium associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.78 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 1.13 Pain Relevance 0.48
No need for C3 synthesis by joint-resident cells
Gene_expression (synthesis) of C3 in joint
4) Confidence 0.78 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.13 Pain Relevance 0.03
The hypothesis that local C3 production is important in RA arose from the finding that more C3 is produced in rheumatoid synovium than in osteoarthritic synovium, as determined qualitatively or quantitatively using in situ hybridization to detect messenger RNA (mRNA) for C3 (28,30).
Gene_expression (produced) of C3 in synovium associated with rheumatoid arthritis and osteoarthritis
5) Confidence 0.78 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 1.05 Pain Relevance 0.44
Circulating C3 was measured by enzyme-linked immunosorbent assay (ELISA) and correlated perfectly with the capacity of the recipient to synthesize C3 (26).
Gene_expression (synthesize) of C3
6) Confidence 0.68 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.21 Pain Relevance 0.16
Subsequently, several microarray analyses of synovial gene expression in either human patients or rodent models have yielded conflicting data on this point, sometimes showing an increase in synthesis of C3 (41,42) and sometimes not showing such an increase (43–45).
Gene_expression (synthesis) of C3
7) Confidence 0.68 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.70 Pain Relevance 0.31
Therefore, we generated mice whose joint-resident cells could not synthesize C3 but whose circulation carried C3 that had been synthesized by cells distant from the joint.
Neg (not) Gene_expression (synthesize) of C3 in joint
8) Confidence 0.68 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.06 Pain Relevance 0.03
Therefore, we generated mice whose joint-resident cells could not synthesize C3 but whose circulation carried C3 that had been synthesized by cells distant from the joint.
Gene_expression (synthesized) of C3 in joint
9) Confidence 0.68 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.06 Pain Relevance 0.03
Pratt et al. have elegantly demonstrated that intrarenal production of C3 is essential for graft rejection in a renal allograft model 9.
Gene_expression (production) of C3 associated with graft vs host disease
10) Confidence 0.61 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.76 Pain Relevance 0.12
The aim of this study was to test, in a mouse model of rheumatoid arthritis, whether C3 synthesized within the synovium is important in promoting inflammation.


Gene_expression (synthesized) of C3 in synovium associated with inflammation and rheumatoid arthritis
11) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Abstract Doc Link PMC2559465 Disease Relevance 0.73 Pain Relevance 0.33
In bone marrow chimeras, synthesis of C3 by radioresistant cells was necessary and sufficient to confer susceptibility to serum-transferred arthritis.
Gene_expression (synthesis) of C3 in bone marrow associated with arthritis
12) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Abstract Doc Link PMC2559465 Disease Relevance 0.90 Pain Relevance 0.36
Production of C3 by the inflamed synovium from patients with RA has also been demonstrated (28), and both hematopoietic and nonhematopoietic cells were implicated as potential sources (29,30), leading to the proposal that local synthesis of C3 might be important in propagating inflammation (30).
Gene_expression (synthesis) of C3 in synovium associated with inflammation and rheumatoid arthritis
13) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.43 Pain Relevance 0.19
Production of C3 by the inflamed synovium from patients with RA has also been demonstrated (28), and both hematopoietic and nonhematopoietic cells were implicated as potential sources (29,30), leading to the proposal that local synthesis of C3 might be important in propagating inflammation (30).
Gene_expression (Production) of C3 in synovium associated with inflammation and rheumatoid arthritis
14) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.48 Pain Relevance 0.22
As illustrated in Figure 3A, the irradiated WT partner in these pairs harbored parenchymal cells that produce C3 and introduce it into the circulation, but lacked hematopoietic cells that might produce C3.
Gene_expression (produce) of C3 in hematopoietic cells
15) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.06 Pain Relevance 0.06
Immunofluorescence staining of ankle joints confirmed that C3 was prominently deposited on the cartilage surface and in the synovium, even in animals whose only source of C3 was through the circulation (Figure 4).
Gene_expression (source) of C3 in synovium
16) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.09 Pain Relevance 0.09
A requirement for C3 synthesis by radioresistant cells
Gene_expression (synthesis) of C3
17) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.06 Pain Relevance 0.08
A few years ago, one might have assumed that the obligatory source of C3 and other essential complement components would be the liver.
Gene_expression (source) of C3 in liver
18) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.44 Pain Relevance 0.24
C3 cannot be produced by hematopoietic cells derived from either partner: the WT mouse lacks endogenous hematopoietic cells due to the irradiation, while the C3?
Gene_expression (produced) of C3 in hematopoietic cells
19) Confidence 0.60 Published 2007 Journal Arthritis and Rheumatism Section Body Doc Link PMC2559465 Disease Relevance 0.13 Pain Relevance 0.11
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Gene_expression (express) of acylation stimulating protein in Adipocytes associated with obesity and cytokine
20) Confidence 0.58 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.50 Pain Relevance 0.13

General Comments

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