INT1782

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2009
Negated 32
Speculated 12
Reported most in Abstract
Documents 125
Total Number 145
Disease Relevance 22.00
Pain Relevance 55.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 17
pituitary 14
brain 4
thyroid 3
EPI 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 289 100.00 Very High Very High Very High
agonist 209 100.00 Very High Very High Very High
antagonist 183 100.00 Very High Very High Very High
Somatostatin 177 100.00 Very High Very High Very High
Morphine 117 100.00 Very High Very High Very High
narcan 64 100.00 Very High Very High Very High
methadone 61 100.00 Very High Very High Very High
opiate 49 100.00 Very High Very High Very High
Opioid 42 100.00 Very High Very High Very High
Intracerebroventricular 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 216 100.00 Very High Very High Very High
Arthritis 40 99.98 Very High Very High Very High
Pancreatitis 20 99.84 Very High Very High Very High
Hyperglycemia 2 99.80 Very High Very High Very High
Hypoglycemia 15 99.74 Very High Very High Very High
Rheumatoid Arthritis 105 99.60 Very High Very High Very High
Hypotension 7 99.36 Very High Very High Very High
Obesity 121 99.32 Very High Very High Very High
Schizophrenia 220 99.16 Very High Very High Very High
Thyroid Disease 32 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By contrast, chronic naloxone treatment of female rats reduced basal GH levels by 64% without affecting GH pulse amplitudes or pulse frequency.
Neg (without) Regulation (affecting) of GH associated with narcan
1) Confidence 0.62 Published 1993 Journal Life Sci. Section Abstract Doc Link 8385257 Disease Relevance 0 Pain Relevance 0.67
Yohimbine did not affect serum GH levels in separated two-day-old pups (i.e. basal levels of the hormone), but prevented the nursing-induced increase in serum GH concentration.
Neg (not) Regulation (affect) of GH
2) Confidence 0.61 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.48
In two-day-old pups, clonidine had no effect on basal GH levels but, like yohimbine, prevented the increase in serum GH normally associated with nursing.
Neg (no) Regulation (effect) of GH associated with clonidine
3) Confidence 0.61 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.51
Apomorphine (0.5 mg/kg i.p.) had no effect on plasma GH levels, whereas clonidine (0.5 mg/kg i.p.) induced release of GH in both antiserum treated and control rats.
Neg (no) Regulation (effect) of GH in plasma associated with clonidine
4) Confidence 0.61 Published 1981 Journal Neuroendocrinology Section Abstract Doc Link 6114446 Disease Relevance 0 Pain Relevance 0.26
MSG-treated animals which were administered antisomatostatin serum showed elevated GH trough and mean GH levels, with no apparent effect on GH peak levels.
Neg (no) Regulation (effect) of GH
5) Confidence 0.61 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.21 Pain Relevance 0.15
These data confirmed and extended previous reports from this laboratory on the inhibitory role of beta-adrenergic receptors on GH regulation.
Regulation (regulation) of GH
6) Confidence 0.61 Published 1982 Journal J. Endocrinol. Section Abstract Doc Link 7119644 Disease Relevance 0 Pain Relevance 0.85
The aim of this study was to evaluate whether in infant rats, as in adult rats, the brain adrenergic mechanisms regulate plasma GH levels and, if so, to determine the contribution of GH-releasing hormone (GHRH) and/or somatostatin (SS) pathways.
Spec (whether) Regulation (regulate) of GH in plasma associated with somatostatin
7) Confidence 0.60 Published 1987 Journal Endocrinology Section Abstract Doc Link 2881775 Disease Relevance 0 Pain Relevance 0.30
In the present study the alpha receptors involved in GH regulation were characterized with respect to subtype.
Regulation (regulation) of GH
8) Confidence 0.59 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6291085 Disease Relevance 0 Pain Relevance 0.32
In rats anesthetized with ketamine, which induces a significant increase of GH, PRL and corticosterone secretion by activating the sympathetic tone, OFQ (23 microg/rat, i.c.v.) did not modify GH and corticosterone levels, whereas again it significantly potentiated PRL secretion.
Neg (not) Regulation (modify) of GH in sympathetic associated with ketamine
9) Confidence 0.59 Published 2002 Journal Brain Res. Section Abstract Doc Link 12031535 Disease Relevance 0 Pain Relevance 0.38
The data indicate that alprazolam, but not diazepam, activates brain alpha 2-adrenoceptors involved in rat GH regulation.
Regulation (regulation) of GH in brain
10) Confidence 0.59 Published 1986 Journal Life Sci. Section Abstract Doc Link 2871466 Disease Relevance 0 Pain Relevance 0.36
Long-term (16 days) treatment with the tricyclic antidepressant, imipramine (5 mg/kg/day), the 5-HT uptake inhibiting antidepressant, fluoxetine (2.5 mg/kg/day), and the noradrenergic uptake inhibiting antidepressant, desipramine (5 mg/kg/day), accentuated clonidine's effect on GH levels.
Regulation (effect) of GH associated with desipramine, antidepressant, tricyclic antidepressant, clonidine and fluoxetine
11) Confidence 0.57 Published 1996 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 8951963 Disease Relevance 0.24 Pain Relevance 1.08
Furthermore AIA affects significantly neither hypothalamic somatostatin and GHRH mRNA levels nor pituitary GH content.
Neg (neither) Regulation (affects) of GH in pituitary associated with somatostatin and arthritis
12) Confidence 0.55 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.89 Pain Relevance 0.67
These results indicate that the impact of AIA on GH regulation occurs at the pituitary but not the hypothalamic level and suggest that increased GH secretion observed in AIA rats is an adaptive mechanism involved in the regulation of the inflammatory process.
Regulation (regulation) of GH in pituitary associated with inflammation and arthritis
13) Confidence 0.55 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.92 Pain Relevance 0.64
GH and prolactin secretory patterns were not affected by 6-hydroxydopamine disruption of catecholamine terminals in the PO/AHA.
Neg (not) Regulation (affected) of GH associated with catecholamine
14) Confidence 0.54 Published 1986 Journal Brain Res. Bull. Section Abstract Doc Link 3742252 Disease Relevance 0 Pain Relevance 0.23
GH responses to adrenergic agonists and the failure of 6-hydroxydopamine to affect GH secretory patterns indicate that PO/AHA norepinephrine afferents do not facilitate GH secretion.
Regulation (affect) of GH associated with agonist
15) Confidence 0.54 Published 1986 Journal Brain Res. Bull. Section Abstract Doc Link 3742252 Disease Relevance 0 Pain Relevance 0.22
In female rats gonadectomy did not significantly affect the GH releasing effect of clonidine.
Neg (not) Regulation (affect) of GH associated with clonidine
16) Confidence 0.53 Published 1988 Journal J. Neural Transm. Section Abstract Doc Link 3126262 Disease Relevance 0 Pain Relevance 0.48
Administration of naloxone (250 micrograms/rat), 30 or 60 min before sacrifice, or dexamethasone (100 micrograms/injection), 60 and 120 min before sacrifice, prevented a response to GH without affecting circulating levels of GH.
Neg (without) Regulation (affecting) of GH associated with narcan and dexamethasone
17) Confidence 0.49 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3033537 Disease Relevance 0.61 Pain Relevance 0.26
Intravenous administration of apomorphine (.03 and .1 mg/kg) had no effect on decreased GH levels, whereas clonidine (150 micrograms/kg) restored GH secretion.
Neg (no) Regulation (effect) of GH associated with clonidine
18) Confidence 0.49 Published 1977 Journal Endocrinology Section Abstract Doc Link 233821 Disease Relevance 0 Pain Relevance 0.23
In conclusion, there is in the spontaneously diabetic rat an increased in vivo and in vitro GH responsiveness to exogenous hGRF suggesting an abnormality of GH regulation at the pituitary level.
Regulation (regulation) of GH in pituitary associated with diabetes mellitus
19) Confidence 0.48 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 2888037 Disease Relevance 0.66 Pain Relevance 0.10
Both IGF-1 and GH were controlled in 73.1% of switch and 30.4% of “other” patients.
Regulation (controlled) of GH
20) Confidence 0.45 Published 2009 Journal Pituitary Section Abstract Doc Link PMC2855862 Disease Relevance 0.13 Pain Relevance 0.04

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