INT178202

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Context Info
Confidence 0.34
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.69
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr7) signal transduction (Tlr7) endoplasmic reticulum (Tlr7)
plasma membrane (Tlr7) intracellular (Tlr7) lysosome (Tlr7)
Tlr7 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 4 100.00 Very High Very High Very High
agonist 21 99.04 Very High Very High Very High
Inflammation 11 99.04 Very High Very High Very High
Inflammatory response 1 97.12 Very High Very High Very High
tolerance 5 72.44 Quite High
cytokine 36 63.92 Quite High
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 13 99.04 Very High Very High Very High
Autoimmune Disease 4 97.48 Very High Very High Very High
Targeted Disruption 9 95.04 Very High Very High Very High
Experimental Melanoma 1 91.48 High High
Liver Cancer 1 80.96 Quite High
Infection 38 79.72 Quite High
Hepatitis B Virus Infection 5 79.32 Quite High
Systemic Lupus Erythematosus 5 78.00 Quite High
Disease 13 75.60 Quite High
Cancer 205 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic analysis of TLR7 determined that a modest increase in TLR7 expression resulted in spontaneous development of autoimmunity and a substantial increase in TLR7 expression caused fatal acute inflammation and profound DC dysregulation, indicating that TLR7 must be tightly regulated in order to prevent spontaneous triggering of harmful autoreactive and inflammatory responses [171].
Regulation (regulated) of TLR7 associated with targeted disruption, inflammatory response, autoimmune disease and inflammation
1) Confidence 0.34 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635754 Disease Relevance 0.83 Pain Relevance 0.22
or IFN regulated chemokines such as IP-10 and I-TAC (TLR7).
Regulation (regulated) of TLR7 associated with chemokine
2) Confidence 0.21 Published 2004 Journal J Transl Med Section Body Doc Link PMC441417 Disease Relevance 0.86 Pain Relevance 0.37

General Comments

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