INT17821

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Context Info
Confidence 0.32
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.19
Pain Relevance 1.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Pls1) cellular_component (Pls1) biological_process (Pls1)
cytoplasm (Pls1)
Anatomy Link Frequency
paw 1
posterior pituitary 1
Pls1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 100.00 Very High Very High Very High
allodynia 5 99.18 Very High Very High Very High
fortral 3 99.16 Very High Very High Very High
ischemia 1 99.04 Very High Very High Very High
Morphine 2 98.64 Very High Very High Very High
antagonist 3 97.66 Very High Very High Very High
guanethidine 1 95.04 Very High Very High Very High
Clonidine 2 92.80 High High
reflex sympathetic dystrophy 1 90.04 High High
cytokine 1 89.28 High High
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 6 100.00 Very High Very High Very High
Neuropathic Pain 6 99.18 Very High Very High Very High
Cv Unclassified Under Development 1 99.04 Very High Very High Very High
Reperfusion Injury 1 98.68 Very High Very High Very High
Stress 2 97.98 Very High Very High Very High
Pancreatitis 8 89.40 High High
Increased Venous Pressure Under Development 5 75.00 Quite High
Fibrosis 2 62.88 Quite High
INFLAMMATION 1 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the effectiveness of antisympathetic agents and sympathetic vasoconstrictor antagonists, as well as agents that are vasodilators, in relieving mechanical allodynia in a recently developed animal model of CRPS-I (chronic postischemia pain or CPIP) produced by 3 hours of hind paw ischemia-reperfusion injury.
Gene_expression (produced) of CRPS-I in paw associated with complex regional pain syndromes, pain, reperfusion injury, allodynia, ischemia and antagonist
1) Confidence 0.32 Published 2008 Journal J Pain Section Abstract Doc Link 18262849 Disease Relevance 1.54 Pain Relevance 1.22
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Gene_expression (product) of OTNP-I in posterior pituitary associated with stress
2) Confidence 0.09 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
When administered alone, morphine, cyclazocine, pentazocine, dl-N-allylnormetazocine (NANM), d-NANM, I-NANM and phencyclidine each produced dose-related decreases in accuracy and response rate.
Gene_expression (produced) of I-NANM associated with fortral and morphine
3) Confidence 0.02 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3336001 Disease Relevance 0 Pain Relevance 0.43
In rats treated with maximal doses of cerulein and TGFbeta antibodies, pancreatic hydroxyproline content and expression of collagens I and III and of TGFbeta1 were significantly reduced.
Gene_expression (expression) of collagens I
4) Confidence 0.01 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.55 Pain Relevance 0.13

General Comments

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