INT178222

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.06
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Yy1) chromosome organization (Yy1) RNA binding (Yy1)
plasma membrane (Yy1) nucleus (Yy1) intracellular (Yy1)
Anatomy Link Frequency
bladder 1
Yy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 255 95.28 Very High Very High Very High
Serotonin 1 89.92 High High
Catecholamine 1 88.88 High High
Inflammatory response 31 84.72 Quite High
Acupuncture 2 30.20 Quite Low
aspirin 2 25.04 Quite Low
interstitial cystitis 11 24.00 Low Low
spastic colon 11 23.08 Low Low
cOX1 1 22.24 Low Low
COX2 1 21.52 Low Low
Disease Link Frequency Relevance Heat
Overactive Bladder 183 99.16 Very High Very High Very High
INFLAMMATION 232 95.28 Very High Very High Very High
Stress 137 91.68 High High
Cirrhosis 6 89.84 High High
Targeted Disruption 25 89.12 High High
Cardiovascular Disease 1 87.40 High High
Polycystic Kidney Disease 3 84.64 Quite High
Hyperglycemia 2 81.84 Quite High
Diabetes Mellitus 14 71.32 Quite High
Hypertension 1 70.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in the inflamed mucosa YY1 was not expressed and SRF was considered over-represented (Figure 2).
Neg (not) Gene_expression (expressed) of YY1
1) Confidence 0.57 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.07 Pain Relevance 0
YY1, SF-1, and EF2 were found upstream of ambladder (RIKEN clone 9530014P05 or prothymosin alpha).
Gene_expression (found) of YY1
2) Confidence 0.57 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.27 Pain Relevance 0
, SP-1, STAT-3/-5, YY1).
Gene_expression (/) of YY1
3) Confidence 0.48 Published 2007 Journal Genome Biol Section Body Doc Link PMC2375038 Disease Relevance 1.23 Pain Relevance 0.39
The regulatory network for the control bladder mucosa (MC) was obtained in comparison to detrusor control and contained the following over-represented TREs: GA-binding protein (GABP), YY1 (yin yang 1), SF-1 (steroidogenic factor-1), EF2, CRE-BP1, and Sp-3 (trans-acting transcription factor 3).
Gene_expression (represented) of YY1 in bladder associated with overactive bladder
4) Confidence 0.43 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.31 Pain Relevance 0.08
The TCM theory of yin and yang describes this same phenomenon.
Gene_expression (theory) of yang
5) Confidence 0.01 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442118 Disease Relevance 0.20 Pain Relevance 0.09

General Comments

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