INT178246

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.27
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
liver 4
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 271 100.00 Very High Very High Very High
antagonist 12 88.56 High High
Kinase C 1 76.24 Quite High
agonist 6 41.28 Quite Low
Central nervous system 2 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 144 100.00 Very High Very High Very High
Freckles 204 99.16 Very High Very High Very High
Cancer 50 98.80 Very High Very High Very High
Liver Cancer 22 96.36 Very High Very High Very High
Body Weight 26 92.40 High High
Syndrome 14 89.32 High High
Hyperplasia 10 80.44 Quite High
Hyperinsulinism 14 78.64 Quite High
Skin Cancer 6 78.08 Quite High
Hyperglycemia 8 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Through which signaling pathway does ASIP/MC1R induce biological effects, if not through reduced cAMP?
Negative_regulation (does) of Neg (not) Gene_expression (induce) of ASIP associated with melanocortin 1 receptor
1) Confidence 0.43 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.08 Pain Relevance 0.30
In addition, mutations in Agouti or Atrn that reduce protein expression or activity lead to melanism; these knock-out mutations are certainly more likely to occur than the gain-of-function Mc1r mutations that cause melanism because there are more ways to “break” a gene than to “improve” a gene's activity.
Negative_regulation (reduce) of Gene_expression (expression) of Agouti associated with targeted disruption, melanocortin 1 receptor and freckles
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.82 Pain Relevance 0.68
While variation in the Mc1r coding region does not correlate with melanism in any population, in a New Hampshire population, we find that a 125-kb deletion, which includes the upstream regulatory region and exons 1 and 2 of Agouti, results in a loss of Agouti expression and is perfectly associated with melanic color.
Negative_regulation (loss) of Gene_expression (expression) of Agouti associated with melanocortin 1 receptor and freckles
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2713407 Disease Relevance 0.70 Pain Relevance 0.37
The Agouti sequence possesses neither the aQ65term nor the a?
Neg (neither) Negative_regulation (possesses) of Gene_expression (sequence) of Agouti
4) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.55 Pain Relevance 0.16
125kb alleles, levels of Agouti expression were significantly higher than those of animals homozygous for a?
Negative_regulation (levels) of Gene_expression (expression) of Agouti
5) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.21 Pain Relevance 0.14
Functional agouti protein in the liver of transgenic mice was assayed by its ability to inhibit binding of the ?
Negative_regulation (assayed) of Gene_expression (protein) of agouti in liver associated with targeted disruption
6) Confidence 0.33 Published 2004 Journal Mol Cancer Section Abstract Doc Link PMC443512 Disease Relevance 1.20 Pain Relevance 0.22
In fact, the number of tumors per liver in the transgenic mice was correlated with their level of agouti expression in the liver.
Negative_regulation (level) of Gene_expression (expression) of agouti in liver associated with targeted disruption and cancer
7) Confidence 0.33 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.71 Pain Relevance 0
Comparing Agouti expression in P. polionotus to its sister species P. maniculatus, we find that the increased expression in beach mice is a derived trait because both P. p. subgriseus and P. maniculatus have similarly low levels of Agouti expression.
Negative_regulation (levels) of Gene_expression (expression) of Agouti
8) Confidence 0.31 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.32

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