INT178247

Context Info Confidence 0.31 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 11 Total Number 12 Disease Relevance 8.57 Pain Relevance 2.30

growth (Re)

Anatomy Link Frequency liver 2 basophils 1 mast cells 1 Re (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 320 99.30 lidocaine 306 98.72 Inflammatory mediators 7 66.72 palliative 2 54.68 cytokine 156 53.84 melanocortin 1 receptor 33 18.92 isoflurane 105 5.00 chemokine 45 5.00 Inflammatory response 27 5.00 local anesthetic 18 5.00

Disease Link Frequency Relevance Heat Cancer 75 99.36 INFLAMMATION 351 99.30 Targeted Disruption 209 98.82 Respiratory Syncytial Virus 224 98.24 Liver Cancer 33 93.44 Infection 151 92.76 Body Weight 47 87.12 Peritonitis 18 85.36 Disease 93 84.68 Cerebral Malaria 236 81.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Genome replication occurs via the production of a positive sense replicative intermediate (RI) RNA strand by the same viral RNA polymerase; this RI RNA is used as a template for the synthesis of more negative sense genome [11-13].

Gene_expression (production) of RI

1) Confidence 0.31 Published 2010 Journal Virol J Section Body Doc Link PMC2954858 Disease Relevance 1.03 Pain Relevance 0.08

In mice treated with zymosan alone, Ri was ?

Gene_expression (was) of Ri

2) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.23 Pain Relevance 0.72

Among these, S100A9 was present in exudates within 4 h of initiating inflammation and reached maximum levels at the onset of Ri (12 h).

Gene_expression (onset) of Ri associated with inflammation

3) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.68 Pain Relevance 0.54

max and shifted the onset of Ri from 12 h to a later time point (Tmax?

Gene_expression (onset) of Ri

4) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.42 Pain Relevance 0.87

However, whilst Palivizumab therapy was also able to reduce levels of infectious virus, it failed to prevent production of intracellular RI RNA.

Gene_expression (production) of RI

5) Confidence 0.24 Published 2010 Journal Virol J Section Abstract Doc Link PMC2954858 Disease Relevance 0.95 Pain Relevance 0

Three mice from each of the transgenic and control groups were euthanized at various times after DEN injection, and it was determined that 36 and 40 weeks post-injection were the most appropriate times for sampling the mice, because tumors at those ages were macroscopically visible and had not yet coalesced (data not shown).

Gene_expression (injection) of DEN associated with targeted disruption and cancer

6) Confidence 0.18 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.48 Pain Relevance 0

At 36 weeks after DEN injection, the number of tumors per liver was 2.3 ± 0.4 (mean ± one standard error of the mean) for the controls, 3.5 ± 0.7 for alb-agouti 83, and 4.0 ± 0.9 for alb-agouti 86 (Figure 5A).

Gene_expression (injection) of DEN in liver associated with cancer

7) Confidence 0.18 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.48 Pain Relevance 0

At 40 weeks after DEN injection, the mean number of tumors per liver for the controls, and the alb-agouti 83 and 86 mice was 4.1 ± 1.1, 6.8 ± 1.6, and 10.4 ± 2.5, respectively (Figure 5A).

Gene_expression (injection) of DEN in liver associated with cancer

8) Confidence 0.18 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.26 Pain Relevance 0

RI expression by the mast cells varied between patient samples, IgE receptors were upregulated in all the samples tested.

Gene_expression (expression) of RI in mast cells

9) Confidence 0.01 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.20 Pain Relevance 0

RI) expression after stimulation by IgEs in the patient's sera.

Gene_expression (expression) of RI

10) Confidence 0.01 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0 Pain Relevance 0.05

RI expression was induced after incubation with all serum samples at non-cytotoxic dilutions.

Gene_expression (expression) of RI

11) Confidence 0.01 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.29 Pain Relevance 0

RI is expressed only on mast cells and/or basophils in both mice and humans [9,16].

Gene_expression (expressed) of RI in basophils

12) Confidence 0.01 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

This test has worked.