INT178248

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 1.00
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
melanocytes 2
tube 1
liver 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 247 99.92 Very High Very High Very High
agonist 20 92.16 High High
tolerance 2 35.24 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 77 100.00 Very High Very High Very High
Liver Cancer 11 98.92 Very High Very High Very High
Cancer 25 94.88 High High
Hyperinsulinism 7 70.20 Quite High
Obesity 33 69.40 Quite High
Lung Cancer 1 57.64 Quite High
Body Weight 13 32.00 Quite Low
Diabetes Mellitus 11 7.32 Low Low
Hepatocellular Cancer 1 7.04 Low Low
Sprains And Strains 23 5.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lastly, as seen in Figure 5C, melanocytes cultured in the absence of added melanocortin showed similar decreases in cAMP level with either ASIP or ASIP-YY.
Negative_regulation (decreases) of ASIP-YY in melanocytes
1) Confidence 0.43 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
Lastly, as seen in Figure 5C, melanocytes cultured in the absence of added melanocortin showed similar decreases in cAMP level with either ASIP or ASIP-YY.
Negative_regulation (decreases) of ASIP in melanocytes
2) Confidence 0.43 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.05
There were some minor differences in outcomes, for example they saw a reduction in pheomelanin content with ASIP alone and we did not; these may be attributable to differences in protocol (for example our longer treatment times), in exact culture conditions or in cell passage level.
Negative_regulation (reduction) of ASIP
3) Confidence 0.38 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0
This was the only tested biological effect of ASIP not diminished in melan-mg and -md cells.
Neg (not) Negative_regulation (diminished) of ASIP
4) Confidence 0.38 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.04
l 20× TaqMan gene expression assay of Agouti, Mc1r, and beta-Actin.
Negative_regulation (assay) of Agouti associated with melanocortin 1 receptor
5) Confidence 0.36 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.23
The alb-agouti transgenic mice presented here have agouti expressed only in the liver and, although they are lean and normoinsulinemic, are predisposed to an increased number of liver tumors.
Negative_regulation (predisposed) of agouti in liver associated with liver cancer and targeted disruption
6) Confidence 0.33 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.00 Pain Relevance 0
Subsequent reverse transcriptase reactions were performed using the Titan One tube RT-PCR kit (Roche, http://www.roche.com) with specific Peromyscus primers of Agouti (forward 5?
Negative_regulation (primers) of Agouti in tube
7) Confidence 0.31 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.09

General Comments

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