INT178249

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Context Info
Confidence 0.35
First Reported 2004
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.30
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
dorsum 4
liver 4
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 213 100.00 Very High Very High Very High
agonist 6 27.40 Quite Low
antagonist 9 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 207 99.42 Very High Very High Very High
Sprains And Strains 6 98.96 Very High Very High Very High
Liver Cancer 33 94.36 High High
Hyperinsulinism 21 93.52 High High
Hyperglycemia 12 92.80 High High
Obesity 99 92.20 High High
Syndrome 21 91.60 High High
Cancer 75 81.44 Quite High
Hyperplasia 15 80.60 Quite High
Body Weight 39 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BAPa20 is a line of transgenic mice in which the wild-type agouti cDNA is under the regulatory control of the human ?
Regulation (control) of Gene_expression (cDNA) of agouti associated with targeted disruption
1) Confidence 0.35 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.76 Pain Relevance 0
In order to quantify levels of agouti expression in the livers of various strains of mice (Fig. 2), a Northern blot containing ~2.5 ?
Regulation (levels) of Gene_expression (expression) of agouti in livers associated with sprains and strains
2) Confidence 0.35 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.30 Pain Relevance 0
Specifically, we performed parallel expression analyses for Mc1r, Agouti, and beta-Actin (a ubiquitously expressed control gene) mRNAs in the two polionotus subspecies.
Spec (analyses) Regulation (control) of Gene_expression (expressed) of Agouti associated with melanocortin 1 receptor
3) Confidence 0.33 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.39
As a control, we compared patterns of Mc1r and Agouti expression in skin taken from the dorsum, a region that shows similar levels of pigmentation in beach and mainland subspecies and thus should show little difference in Mc1r and Agouti expression.
Neg (little) Regulation (difference) of Gene_expression (expression) of Agouti in dorsum associated with melanocortin 1 receptor
4) Confidence 0.33 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.51
As a control, we compared patterns of Mc1r and Agouti expression in skin taken from the dorsum, a region that shows similar levels of pigmentation in beach and mainland subspecies and thus should show little difference in Mc1r and Agouti expression.
Regulation (patterns) of Gene_expression (expression) of Agouti in dorsum associated with melanocortin 1 receptor
5) Confidence 0.33 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.49
To address this question, lines of transgenic mice were generated in which the wild-type agouti cDNA was ectopically expressed only in the liver under the regulatory control of the albumin promoter.
Regulation (under) of Gene_expression (expressed) of agouti in liver associated with targeted disruption
6) Confidence 0.21 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.24 Pain Relevance 0

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