INT17825

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Context Info
Confidence 0.68
First Reported 1991
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 44
Total Number 46
Disease Relevance 12.58
Pain Relevance 28.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Anatomy Link Frequency
midbrain 3
neurons 3
brain 2
fibroblasts 2
plasma 1
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 498 100.00 Very High Very High Very High
Glutamate 222 100.00 Very High Very High Very High
gABA 129 100.00 Very High Very High Very High
sSRI 76 100.00 Very High Very High Very High
Serotonin 73 100.00 Very High Very High Very High
5HT 10 100.00 Very High Very High Very High
monoamine 35 99.98 Very High Very High Very High
narcan 5 99.90 Very High Very High Very High
midbrain 39 99.68 Very High Very High Very High
Gabapentin 328 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 262 99.76 Very High Very High Very High
Schizophrenia 1112 99.72 Very High Very High Very High
Nervous System Injury 19 99.48 Very High Very High Very High
Hypertension 8 99.48 Very High Very High Very High
Pulmonary Hypertension 212 98.72 Very High Very High Very High
Morphine Dependence 7 98.68 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 69 98.64 Very High Very High Very High
Urological Neuroanatomy 24 98.40 Very High Very High Very High
Diabetes Mellitus 61 96.12 Very High Very High Very High
Targeted Disruption 6 96.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection with a single 2.3-kilobase brainstem complementary DNA clone is sufficient to confer expression of a Na(+)-dependent 5HT transporter upon nonneural cells, with transport selectively and potently antagonized by 5HT uptake-specific antidepressants, including paroxetine, citalopram and fluoxetine.
Gene_expression (expression) of transporter in brainstem associated with medulla, antidepressant, 5ht and fluoxetine
1) Confidence 0.68 Published 1991 Journal Nature Section Abstract Doc Link 1944572 Disease Relevance 0.21 Pain Relevance 0.78
Cloning and expression of a functional serotonin transporter from rat brain.
Gene_expression (expression) of transporter in brain associated with serotonin
2) Confidence 0.68 Published 1991 Journal Nature Section Title Doc Link 1944572 Disease Relevance 0.27 Pain Relevance 0.71
The difference in amphetamine self-administration in control and deprived rats cannot be explained by a modification of dopamine transporter expression measured by immunoautoradiography.
Gene_expression (expression) of transporter associated with dopamine
3) Confidence 0.67 Published 2006 Journal Behav Pharmacol Section Abstract Doc Link 17110797 Disease Relevance 0.14 Pain Relevance 0.91
The present results suggest that serotonin is taken up into the IL terminals by a dopamine transporter and is not synthesized in them, at least in vitro.
Gene_expression (taken) of transporter associated with dopamine and serotonin
4) Confidence 0.54 Published 1994 Journal Neurosci. Res. Section Abstract Doc Link 7724065 Disease Relevance 0 Pain Relevance 0.70
Although the serotonin transporter in cultured astrocytes displayed a Km value approximately 10 times greater than found in adult brain synaptosomes, these observations indicated that astrocytes in vitro may express the same serotonin transporter as neurons.
Gene_expression (express) of transporter in adult brain associated with serotonin
5) Confidence 0.42 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9694037 Disease Relevance 0 Pain Relevance 0.56
Monoamine transporter expression was differentially altered by cocaine; dopamine transporter mRNA levels in the ventral tegmental area, but not in the substantia nigra, were increased following withdrawal from cocaine, suggesting a role for the upregulated mesolimbic dopamine transporter in the mechanisms underlying relapse to cocaine taking.
Gene_expression (expression) of transporter in substantia nigra associated with ventral tegmentum, dopamine, substantia nigra, withdrawal, recurrence, cocaine and monoamine
6) Confidence 0.39 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072100 Disease Relevance 0.09 Pain Relevance 1.22
Reverse transcriptase-PCR demonstrated that astrocytes in culture expressed messenger RNA for the cloned serotonin transporter protein which has been characterised as the neuronal serotonin transporter.
Gene_expression (expressed) of transporter in astrocytes associated with serotonin
7) Confidence 0.37 Published 1998 Journal Neurochem. Int. Section Abstract Doc Link 9694037 Disease Relevance 0 Pain Relevance 0.45
In addition, maternal separation produces a reduction in glial excitatory amino acid transporter (EAAT)-1 with no change in EAAT-2 or gamma-amino butyric acid transporters.
Gene_expression (produces) of transporter
8) Confidence 0.26 Published 2010 Journal Gastroenterology Section Body Doc Link 20226190 Disease Relevance 0.12 Pain Relevance 0
By Northern blot analysis, the expression of glial glutamate transporter GLT-1, but not GLAST, mRNA was decreased in the striatum/nucleus accumbens (NAc) and thalamus of morphine-dependent rats.
Gene_expression (expression) of transporter in thalamus associated with nucleus accumbens, glutamate, thalamus and morphine
9) Confidence 0.18 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542740 Disease Relevance 0.34 Pain Relevance 1.44
Even after denervation of the tail artery (by cutting the postganglionic nerves, Fig. 3(3)) to remove the perivascular terminals (and thus the NE transporter), the responses to phenylephrine were much more enhanced relative to control than those to another ?
Gene_expression (thus) of transporter in artery
10) Confidence 0.14 Published 2007 Journal Clin Auton Res Section Body Doc Link PMC1797061 Disease Relevance 0 Pain Relevance 0.15
In addition to neurons, glial cells have also been shown to express functional NE transporter sites and may exert significant control of noradrenergic activity by inactivating NE that escapes neuronal re-uptake at sites distant from terminals (Henn and Hamburger 1971).
Gene_expression (express) of transporter in glial cells
11) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654524 Disease Relevance 0 Pain Relevance 0.03
We found that mRNA of the serotonin transporter (SERT), a target of SSRIs, was expressed in rat-1 fibroblasts.
Gene_expression (expressed) of transporter in fibroblasts associated with ssri and serotonin
12) Confidence 0.11 Published 2008 Journal Life Sci. Section Abstract Doc Link 18482738 Disease Relevance 0.17 Pain Relevance 0.52
Immunoblot analysis showed that expression of GLT1 (glutamate transporter subtype 1) was identified to be upregulated in synaptosomes but not in total tissues, suggesting a redistribution of glutamate transporter expression.
Gene_expression (expression) of transporter associated with glutamate
13) Confidence 0.11 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.16
Immunoblot analysis showed that expression of GLT1 (glutamate transporter subtype 1) was identified to be upregulated in synaptosomes but not in total tissues, suggesting a redistribution of glutamate transporter expression.
Gene_expression (expression) of transporter associated with glutamate
14) Confidence 0.11 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.16
Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses.
Gene_expression (expression) of transporter in synapses associated with glutamate, withdrawal and morphine
15) Confidence 0.09 Published 2003 Journal J. Neurosci. Section Title Doc Link 12805317 Disease Relevance 0 Pain Relevance 1.14
On the other hand, procaine and other LAs had little or no effect on [3H]GABA and [3H]glutamate uptake in COS cells expressing mouse GABA or rat glutamate/aspartate transporter.
Gene_expression (expressing) of transporter associated with glutamate, gaba and local anesthetic
16) Confidence 0.08 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10685879 Disease Relevance 0 Pain Relevance 1.42
Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells.
Gene_expression (expressed) of transporter associated with serotonin
17) Confidence 0.08 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10685879 Disease Relevance 0 Pain Relevance 1.36
Among the LAs tested, procaine and other ester-type LAs inhibited [3H]DA uptake and binding of [3H]2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane (CFT), a cocaine analogue, in COS cells expressing rat dopamine transporter (DAT).
Gene_expression (expressing) of transporter associated with dopamine, cocaine and local anesthetic
18) Confidence 0.08 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10685879 Disease Relevance 0 Pain Relevance 1.15
Gene transfer of GLT-1, a glutamate transporter, into the nucleus accumbens shell attenuates methamphetamine- and morphine-induced conditioned place preference in rats.
Gene_expression (transfer) of transporter in shell associated with nucleus accumbens, glutamate, narcan and morphine
19) Confidence 0.07 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16324108 Disease Relevance 0 Pain Relevance 0.77
Since astroglial glutamate transporters play an important role in maintaining an appropriate level of glutamate extracellular concentration, a reduction in GLT-1 glutamate transporter expression may lead to a build up of glutamate concentration in the synaptic cleft, resulting in neuronal hyperexcitability and behavioral hyperalgesia.
Gene_expression (expression) of transporter in neuronal associated with hyperalgesia, glutamate and hyperexcitability
20) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.84 Pain Relevance 0.98

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