INT178252

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.73
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
skin 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 151 100.00 Very High Very High Very High
antagonist 7 86.44 High High
agonist 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 102 98.68 Very High Very High Very High
Targeted Disruption 71 95.76 Very High Very High Very High
Dislocations 2 78.00 Quite High
Sprains And Strains 8 75.00 Quite High
Obesity 35 50.00 Quite Low
Cancer 25 5.00 Very Low Very Low Very Low
Body Weight 13 5.00 Very Low Very Low Very Low
Liver Cancer 11 5.00 Very Low Very Low Very Low
Diabetes Mellitus 11 5.00 Very Low Very Low Very Low
Syndrome 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To quantify Mc1r and Agouti transcript levels in wild type and melanic mice from New Hampshire, we used quantitative real-time PCR to detect Mc1r and Agouti mRNA in the skin of 4-day-old (P4) pups, a time when Agouti expression is high [52].
Transcription (detect) of Agouti in skin associated with melanocortin 1 receptor
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0 Pain Relevance 0.36
125kb allele produces significantly less Agouti mRNA transcript and is thus likely the cause of melanism.
Transcription (transcript) of Agouti associated with freckles
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.27 Pain Relevance 0.15
The level of agouti mRNA expression in lethal yellow mice was assigned the value of 1.0, and the expression levels in viable yellow mice and transgenic mice were normalized relative to this value.


Transcription (expression) of agouti associated with targeted disruption
3) Confidence 0.56 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.47 Pain Relevance 0
Conversely, beach mice have a derived increase in Agouti mRNA expression but no changes in protein sequence.
Transcription (expression) of Agouti
4) Confidence 0.53 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40

General Comments

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