INT178255

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Context Info
Confidence 0.65
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.72
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (a) generation of precursor metabolites and energy (a) extracellular region (a)
Anatomy Link Frequency
bulbs 2
papilla 1
a (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 91 98.20 Very High Very High Very High
adenocard 1 88.88 High High
agonist 4 55.44 Quite High
antagonist 4 29.60 Quite Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Freckles 55 99.32 Very High Very High Very High
Diabetes Mellitus 11 89.36 High High
Obesity 34 88.88 High High
Microphthalmia 2 74.20 Quite High
Alopecia 1 71.12 Quite High
Sprains And Strains 10 63.68 Quite High
Targeted Disruption 72 50.00 Quite Low
Insulin Resistance 1 16.24 Low Low
Hypertrophy 1 13.28 Low Low
Hyperplasia 5 12.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agouti signaling protein is a soluble protein of 131 amino acids, apparently secreted by dermal papilla cells in hair bulbs.
Localization (secreted) of Agouti signaling protein in bulbs
1) Confidence 0.65 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.14 Pain Relevance 0.34
The mouse agouti gene product is a secreted paracrine factor that regulates the alternate production of black and yellow pigments produced by hair-bulb melanocytes [2-4].
Localization (secreted) of agouti in bulb
2) Confidence 0.63 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.25 Pain Relevance 0.15
Large deletion in Agouti associated with melanism
Localization (deletion) of Agouti associated with freckles
3) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.32 Pain Relevance 0.09
Such pigment switching is controlled by the interaction of two genes: the melanocortin-1 receptor (Mc1r), which encodes a seven-transmembrane receptor expressed in melanocytes, and its ligand, agouti, whose protein product is secreted from nearby dermal papilla cells and acts to inhibit Mc1r signaling.
Localization (secreted) of agouti in papilla associated with melanocortin 1 receptor
4) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.51

General Comments

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